Linares Segovia Benigno, Gutiérrez Tinoco Maximiliano, Izquierdo Arrizon Angeles, Guízar Mendoza Juan Manuel, Amador Licona Norma
Department of Medicine and Nutrition, Guanajuato University, León, Mexico.
Exp Diabetes Res. 2012;2012:684562. doi: 10.1155/2012/684562. Epub 2012 Nov 5.
Recent studies have reported an increase in the prevalence of obesity and metabolic syndrome in children and adolescents. However, few have focused how diabetes mellitus and metabolic syndrome together in parents can influence on obesity and metabolic disturbances in offspring.
To know the risk obesity and metabolic disturbance in children, adolescents, and young adults whose parents have diabetes mellitus and metabolic syndrome.
A comparative survey was made in healthy children of parents with diabetes mellitus and metabolic syndrome compared with offspring of healthy parents. We performed anthropometry and evaluated blood pressure, glucose, total cholesterol, HDL cholesterol, and triglycerides levels in plasma. We registered parent antecedents to diabetes mellitus and metabolic syndrome and investigated the prevalence of overweight, obesity, and metabolic disturbances in offspring.
We studied 259 subjects of 7 to 20 years of age. The prevalence of overweight and obesity was 27% and 37%, respectively. The highest proportion of BMI >95th of the entire group was found in offspring with both diabetic parents. Glucose and total cholesterol levels were lower in the group with healthy parents compared with the group with diabetic mother and metabolic syndrome but with healthy father. HDL cholesterol was higher in the group with both healthy parents than in the group with diabetic mother and metabolic syndrome but healthy father.
The offspring of parents with diabetes plus metabolic syndrome showed higher proportion of variables related to metabolic syndrome compared with healthy parents.
最近的研究报告称儿童和青少年肥胖及代谢综合征的患病率有所上升。然而，很少有研究关注父母同时患有糖尿病和代谢综合征如何影响后代的肥胖和代谢紊乱。
了解父母患有糖尿病和代谢综合征的儿童、青少年及青年发生肥胖和代谢紊乱的风险。
对父母患有糖尿病和代谢综合征的健康儿童与健康父母的后代进行了一项对比调查。我们进行了人体测量，并评估了血压、血糖、总胆固醇、高密度脂蛋白胆固醇和血浆甘油三酯水平。我们记录了父母患糖尿病和代谢综合征的情况，并调查了后代超重、肥胖和代谢紊乱的患病率。
我们研究了259名7至20岁的受试者。超重和肥胖的患病率分别为27%和37%。在父母双方均患有糖尿病的后代中，发现整个组中BMI>第95百分位数的比例最高。与母亲患有糖尿病和代谢综合征但父亲健康的组相比，父母健康组的血糖和总胆固醇水平较低。父母均健康组的高密度脂蛋白胆固醇高于母亲患有糖尿病和代谢综合征但父亲健康的组。
与健康父母相比，父母患有糖尿病加代谢综合征的后代出现与代谢综合征相关变量的比例更高。
