Lifecourse Epidemiology of Adiposity and Diabetes Center, Department of Epidemiology and Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Ann N Y Acad Sci. 2021 Jul;1495(1):99-120. doi: 10.1111/nyas.14573. Epub 2021 Feb 5.
SEARCH for Diabetes in Youth (SEARCH) was initiated in 2000 as a multicenter study to address major gaps in the understanding of childhood diabetes in the United States. An active registry of youth diagnosed with diabetes at age <20 years since 2002 assessed prevalence, annual incidence, and trends by age, race/ethnicity, sex, and diabetes type. An observational cohort nested within the population-based registry was established to assess the natural history and risk factors for acute and chronic diabetes-related complications, as well as the quality of care and quality of life of children and adolescents with diabetes from diagnosis into young adulthood. SEARCH findings have contributed to a better understanding of the complex and heterogeneous nature of youth-onset diabetes. Continued surveillance of the burden and risk of type 1 and type 2 diabetes is important to track and monitor incidence and prevalence within the population. SEARCH reported evidence of early diabetes complications highlighting that continuing the long-term follow-up of youth with diabetes is necessary to further our understanding of its natural history and to develop the most appropriate approaches to primary, secondary, and tertiary prevention of diabetes and its complications. This review summarizes two decades of research and suggests avenues for further work.
SEARCH 糖尿病研究（SEARCH）于 2000 年启动，是一项多中心研究，旨在解决美国儿童糖尿病认识方面的重大空白。自 2002 年以来，一项针对 20 岁以下确诊糖尿病的青年的活跃登记处评估了患病率、年发病率以及按年龄、种族/民族、性别和糖尿病类型的趋势。在人群登记处中嵌套了一个观察队列，以评估急性和慢性糖尿病相关并发症的自然史和危险因素，以及儿童和青少年糖尿病从诊断到成年早期的护理质量和生活质量。SEARCH 的发现有助于更好地理解青少年发病糖尿病的复杂性和异质性。持续监测 1 型和 2 型糖尿病的负担和风险对于跟踪和监测人群中的发病率和患病率非常重要。SEARCH 报告了早期糖尿病并发症的证据，强调需要继续对糖尿病青年进行长期随访，以进一步了解其自然史，并制定最适当的方法，以进行糖尿病及其并发症的一级、二级和三级预防。本综述总结了 20 年的研究，并提出了进一步工作的途径。
