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紫外线和电离辐射对疱疹病毒、SV40和腺病毒的影响与小蚀斑效应的关系。

The effects of ultraviolet and ionizing radiation on herpesviruses, SV40 and adenoviruses in relation to the small-plaque effect.

作者信息

Cameron K R, Tomkins L M, Eglin R P, Ross L J, Wildy P, Russell W C

出版信息

Arch Virol. 1979;62(1):31-40. doi: 10.1007/BF01314901.

DOI:10.1007/BF01314901
PMID:231946
Abstract

The small-plaque effect occurs with a wide range of herpesviruses following irradiation with ultraviolet light. The 37 per cent survival (D37) values, or dose required for one lethal hit (e-1), for herpes simplex, pseudorabies and pigeon herpesviruses in different cells indicate a broad spectrum of host-cell repair capacity. Other DNA-containing viruses such as SV40 and adenoviruses, which also replicate in the cell nucleus, show the small-plaque effect. Ionizing irradiation of herpes simplex virus type 1 (HSV-1) showed but little reduction in plaque-size.

摘要

多种疱疹病毒在紫外线照射后会出现小蚀斑效应。单纯疱疹病毒、伪狂犬病病毒和鸽疱疹病毒在不同细胞中的37%存活(D37)值,即一次致死性损伤(e-1)所需的剂量,表明宿主细胞修复能力范围广泛。其他也在细胞核中复制的含DNA病毒,如SV40和腺病毒,也表现出小蚀斑效应。对1型单纯疱疹病毒(HSV-1)进行电离辐射后,蚀斑大小几乎没有减小。

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本文引用的文献

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A sensitive and precise plaque assay for herpes virus.一种用于疱疹病毒的灵敏且精确的蚀斑测定法。
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Comparative studies of host-cell reactivation, colony forming ability and excision repair after UV irradiation of xeroderma pigmentosum, normal human and some other mammalian cells.着色性干皮病患者细胞、正常人细胞及其他一些哺乳动物细胞经紫外线照射后宿主细胞复活、集落形成能力及切除修复的比较研究
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Host-cell reactivation in mammalian cells. IV. Cell culture conditions affecting virus survival.哺乳动物细胞中的宿主细胞复活。IV. 影响病毒存活的细胞培养条件。
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Aug;26(2):133-41. doi: 10.1080/09553007414551071.