Cardinault Nicolas, Tourniaire Franck, Astier Julien, Couturier Charlene, Bonnet Lauriane, Seipelt Eva, Karkeni Esma, Letullier Claire, Dlalah Naima, Georgé Stephane, Mounien Lourdes, Landrier Jean-Francois
Pollenergie, La Grabère, 47450 Saint Hilaire de Lusignan, France.
Aix Marseille University, C2VN, INRAE, INSERM, 13000 Marseille, France.
Antioxidants (Basel). 2021 Mar 9;10(3):411. doi: 10.3390/antiox10030411.
Propolis extracts are considered as nutraceutical products with potentialities towards obesity and comorbidities management. Nevertheless, propolis extracts composition is highly variable and depends on the botanic origin of plants used by the bees to produce propolis. This study aims to evaluate the differential effect of poplar propolis extract powder (PPEP), propolis extract powder (BPEP), and/ or propolis extract powder (DPEP) on obesity and glucose homeostasis in high-fat-fed mice. PPEP supplementation reduced high-fat (HF)-mediated body weight gain, adiposity index, and improved glucose homeostasis in male C57Bl/6J mice that were submitted to a high-fat diet for 12 weeks, whereas BPEP, DPEP, or a mix of the three PEPs did not modify those parameters. Adipose tissue (AT) gene expression profiling highlighted an induction of mRNA related to lipid catabolism and an inhibition of mRNA coding for inflammatory markers. Several Nrf2 target genes, coding for antioxidant enzymes, were induced in AT under PPEP effect, but not by other PEP. Interestingly, representative PPEP polyphenols mediated the induction of Nrf2 target genes cell-autonomously in adipocytes, suggesting that this induction may be related to the specific polyphenol content of PPEP. Whereas PPEP supplementation has demonstrated a clear potential to blunt the onset of obesity and associated comorbidities, other PEPs (from and ) were inefficient to support their role in preventive nutrition.
蜂胶提取物被认为是具有管理肥胖及合并症潜力的营养保健品。然而，蜂胶提取物的成分高度可变，这取决于蜜蜂用于生产蜂胶的植物的植物来源。本研究旨在评估杨树蜂胶提取物粉末（PPEP）、蜂胶提取物粉末（BPEP）和/或蜂胶提取物粉末（DPEP）对高脂喂养小鼠的肥胖和葡萄糖稳态的不同影响。在接受高脂饮食12周的雄性C57Bl/6J小鼠中，补充PPEP可减少高脂（HF）介导的体重增加、肥胖指数，并改善葡萄糖稳态，而BPEP、DPEP或三种PPEP的混合物并未改变这些参数。脂肪组织（AT）基因表达谱显示与脂质分解代谢相关的mRNA诱导以及编码炎症标志物的mRNA抑制。在PPEP作用下，AT中诱导了几个编码抗氧化酶的Nrf2靶基因，但其他PPEP未诱导。有趣的是，代表性的PPEP多酚在脂肪细胞中自主介导Nrf2靶基因的诱导，这表明这种诱导可能与PPEP的特定多酚含量有关。虽然补充PPEP已显示出明显的潜力来抑制肥胖及相关合并症的发生，但其他PPEP（来自[具体来源未提及]和[具体来源未提及]）在预防性营养中未能有效发挥其作用。
