Laboratório de Química de Produtos Naturais, Centro de Pesquisas "René Rachou"-FIOCRUZ. Cx. Postal 1743, CEP 30190-002, Belo Horizonte, MG - Brazil.
Phytomedicine. 1995 Jul;2(1):47-50. doi: 10.1016/S0944-7113(11)80048-6.
With the aim of finding an acceptable method for selecting plant extracts to be assayed against the infective blood form of Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis), two different strategies were compared: a) screening only medicinal species and b) pre-screening random collected species in the brine shrimp lethality assay (BSLA). Fifty-two plants belonging to the Asteraceae family, including eighteen medicinal species, were collected and their ethanol extracts assayed against both T. cruzi and Artemia salina (brine shrimp). The proportion of trypanocidal extracts among the medicinal species and among the random collection did not differ significantly. On the other hand, the proportion of trypanocidal extracts among those that presented LC(50) of less than 100 ppm to A. salina was four times higher than among the medicinal species.
为了找到一种可接受的方法来选择植物提取物，以对抗引起恰加斯病（美洲锥虫病）的克氏锥虫感染性血液形式，比较了两种不同的策略：a）仅筛选药用物种和 b）在卤虫致死试验（BSLA）中预先筛选随机采集的物种。收集了属于菊科的 52 种植物，包括 18 种药用物种，并对它们的乙醇提取物进行了克氏锥虫和卤虫（盐水虾）的检测。药用物种和随机采集物中的杀锥虫提取物的比例没有显著差异。另一方面，LC（50）低于 100ppm 的 A. salina 的杀锥虫提取物的比例是药用物种的四倍。
