Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Department of Cardiovascular Medicine, The Friendship Hospital of Ili Kazakh Autonomous Prefecture, Yining 835000, Xinjiang, China.
Biosci Rep. 2019 Jan 3;39(1). doi: 10.1042/BSR20181510. Print 2019 Jan 31.
: The aim of the present study is to investigate the association between the single nucleotide polymorphism (SNP) sites of peroxisome proliferator-activated receptor Δ (PPARD) and the risk of coronary artery disease (CAD). To this end, a prospective observational single-center study of the clinical data from 880 subjects in a Chinese population was conducted. : A total of 880 subjects, including 609 CAD patients and 271 control subjects, were selected for the present study. All inpatients had 4 ml of venous blood drawn after 12 h of fasting, and then clinical tests were conducted to obtain the biochemical parameters. CAD patients and Controls were distinguished by coronary angiography. Statistical analysis was conducted with SPSS software (ver 16.0). : A significant association between the G-alleles of PPARD rs3777744 and rs3798343 and a decreased risk for CAD was found. Moreover, we found an interaction between high fasting high-density lipoprotein cholesterol (HDL-C) serum levels, low serum glucose levels and their genotypes, ultimately decreasing the risk of CAD. Haplotype analysis was conducted on the three SNP sites, rs3777744 and rs3798343 to form a block [r = 0.79, D' = 0.99). The A-C haplotypes were associated with an increased risk of CAD (odds ratio (OR), 95% confidence interval (CI): 1.321 (1.060-1.647), =0.013], and the G-G haplotypes were associated with a decreased risk [OR, 95% CI: 0.714 (0.567-0.849), =0.004]. : Our study indicates a significant association between the G-alleles of PPARD rs3777744 and rs3798343 and a decreased CAD risk. In addition, genotypes interact with high serum HDL-C levels and low serum glucose levels, resulting in decreased prevalence of CAD.
: 本研究旨在探讨过氧化物酶体增殖物激活受体 Δ（PPARD）单核苷酸多态性（SNP）位点与冠心病（CAD）风险之间的关联。为此，对中国人群中 880 例患者的临床资料进行了前瞻性观察性单中心研究。: 本研究共纳入 880 例受试者，其中 609 例 CAD 患者和 271 例对照。所有住院患者均禁食 12 小时后抽取 4ml 静脉血，进行临床检查以获得生化参数。通过冠状动脉造影区分 CAD 患者和对照组。采用 SPSS 软件（ver 16.0）进行统计学分析。: PPARD rs3777744 和 rs3798343 的 G 等位基因与 CAD 风险降低显著相关。此外，我们还发现空腹高密度脂蛋白胆固醇（HDL-C）血清水平升高、血清葡萄糖水平降低与基因型之间存在交互作用，最终降低 CAD 风险。对三个 SNP 位点 rs3777744 和 rs3798343 进行单体型分析，形成一个块[ r = 0.79，D'= 0.99）。A-C 单体型与 CAD 风险增加相关（比值比（OR），95%置信区间（CI）：1.321（1.060-1.647），=0.013），而 G-G 单体型与 CAD 风险降低相关[OR，95% CI：0.714（0.567-0.849），=0.004]。: 本研究表明，PPARD rs3777744 和 rs3798343 的 G 等位基因与 CAD 风险降低显著相关。此外，基因型与高血清 HDL-C 水平和低血清葡萄糖水平相互作用，导致 CAD 患病率降低。
