Department of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands.
Psychosom Med. 2013 Jan;75(1):83-9. doi: 10.1097/PSY.0b013e318274d30f. Epub 2012 Nov 28.
Previous research indicates that patients with severe symptoms of depression or anxiety are prone toward the development of dyslipidemia and abdominal obesity. We sought to study these associations longitudinally.
Among 2126 Netherlands Study of Depression and Anxiety participants, we studied whether severity of depressive (Inventory of Depressive Symptoms) or anxiety (Beck Anxiety Inventory) symptoms at baseline was associated with changes in lipids (i.e., total, high-density lipoprotein [HDL] or low-density lipoprotein cholesterol, and triglycerides) or waist circumference during a 2-year follow-up period. We also examined whether changes in severity of symptoms were associated with changes in lipid or waist circumference levels over these 2 years. Multivariate linear regression analyses were adjusted for age, sex, education, and tobacco consumption.
Baseline symptoms of depression or anxiety predicted a decrease in HDL cholesterol (adjusted β = -.062 [p = .003] and β = -.050 [p = .02], respectively) and an increase in waist circumference (adjusted β = .060 [p = .01] and β = .053 [p = .02], respectively) for 2 years. Reduction of symptoms of depression or anxiety over time did not coincide with an amelioration of lipid or waist circumference values.
People with initially severe symptoms of depression or anxiety showed a subsequent decrease in HDL cholesterol levels and an increase in abdominal obesity over time, independent of a potential reduction in symptom severity in this period. Therefore, such people are at elongated and increasing risk for dyslipidemia and obesity, predisposing them to cardiovascular disease.
先前的研究表明，严重抑郁或焦虑症状的患者易发生血脂异常和腹型肥胖。我们旨在进行纵向研究以探讨这些关联。
在 2126 名荷兰抑郁和焦虑研究参与者中，我们研究了基线时抑郁（抑郁症状量表）或焦虑（贝克焦虑量表）症状的严重程度是否与 2 年随访期间的血脂（即总胆固醇、高密度脂蛋白[HDL]或低密度脂蛋白胆固醇和甘油三酯）或腰围变化有关。我们还检查了症状严重程度的变化是否与这 2 年内的血脂或腰围水平的变化有关。多变量线性回归分析调整了年龄、性别、教育程度和吸烟状况。
基线时的抑郁或焦虑症状预示着 HDL 胆固醇降低（调整后的β=-.062 [p=0.003]和β=-.050 [p=0.02]）和腰围增加（调整后的β=0.060 [p=0.01]和β=0.053 [p=0.02]），持续 2 年。随着时间的推移，症状的减轻与血脂或腰围值的改善并不一致。
最初有严重抑郁或焦虑症状的人随着时间的推移，HDL 胆固醇水平持续下降，腹部肥胖持续增加，这与这段时间内症状严重程度的潜在减轻无关。因此，这些人患血脂异常和肥胖的风险延长且增加，使他们易患心血管疾病。
