Fluorescence Imaging Group, Departamento de Física de Materiales, Facultad de Ciencias, Instituto Nicolás Cabrera, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Nanomedicine (Lond). 2013 Mar;8(3):379-88. doi: 10.2217/nnm.12.122. Epub 2012 Dec 2.
This article demonstrates how controlled hyperthermia at the cellular level can be achieved.
MATERIALS & METHODS: The method is based on the simultaneous intracellular incorporation of fluorescence nanothermometers (CdSe quantum dots) and metallic nanoheaters (gold nanorods).
Real-time spectral analysis of the quantum dot emission provides a detailed feedback about the intracellular thermal loading caused by gold nanorods excited at the plasmon frequency. Based on this approach, thermal dosimetry is assessed in such a way that the infrared laser (heating) power required to achieve catastrophic intracellular temperature increments in cancer cells is identified.
This pure optical method emerges as a new and promising guide for the development of infrared hyperthermia therapies with minimal invasiveness.
本文展示了如何在细胞水平实现控制的过热。
该方法基于荧光纳米温度计（CdSe 量子点）和金属纳米加热器（金纳米棒）的同时细胞内掺入。
量子点发射的实时光谱分析为金纳米棒在等离子体频率激发下引起的细胞内热负荷提供了详细的反馈。基于这种方法，以评估热剂量学的方式，确定了实现癌细胞灾难性细胞内温度升高所需的红外激光（加热）功率。
这种纯光学方法为开发具有最小侵入性的红外热疗提供了一种新的有前途的指导。
