Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran.
Colloids Surf B Biointerfaces. 2013 Mar 1;103:652-7. doi: 10.1016/j.colsurfb.2012.10.035. Epub 2012 Nov 1.
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of α-cyclodextrin rings to functionalized polyethylene glycol (PEG) chain with hydrophobic triazine end-groups. Non-covalent interactions between SPIONs and PPRs led to the assembly of SPIONs@PRs hybrid nanomaterials. Measurements of the (1)H Nuclear Magnetic Resonance (NMR) relaxation times T(1) and T(2) allowed us to determine the NMR dispersion profiles. Comparison between our SPIONs@PRs hybrid nano-compound and the commercial SPION compound, Endorem, showed a higher transverse relaxivity for SPIONs@PRs. In vitro MRI experiments showed that our SPIONs@PRs produces better negative contrast compared to Endorem and can be considered as a novel MRI contrast agent.
超顺磁性氧化铁纳米粒子（SPIONs）被合成并包覆上假聚轮烷（PPRs），被提出作为一种用于医学成像和药物输送的新型杂化纳米结构。PPRs 通过将α-环糊精环添加到具有疏水性三嗪端基的功能化聚乙二醇（PEG）链上而制备。SPIONs 和 PPRs 之间的非共价相互作用导致 SPIONs@PRs 杂化纳米材料的组装。（1）H 核磁共振（NMR）弛豫时间 T（1）和 T（2）的测量允许我们确定 NMR 弥散曲线。我们的 SPIONs@PRs 杂化纳米化合物与商业 SPION 化合物 Endorem 的比较表明，SPIONs@PRs 的横向弛豫率更高。体外 MRI 实验表明，与 Endorem 相比，我们的 SPIONs@PRs 产生更好的负对比，可以被认为是一种新型的 MRI 对比剂。
