Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, United States.
Nano Lett. 2010 Nov 10;10(11):4607-13. doi: 10.1021/nl102623x.
We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.
我们描述了一种新的超顺磁性氧化铁纳米粒子（SPIOs）涂层方法，并证明通过精细调整 SPIOs 的核心尺寸和 PEG 涂层，可以将每个粒子的 T2 弛豫率提高 200 倍以上。具有 14nm 核心和 PEG1000 涂层的 SPIOs 的 T2 弛豫率可以达到 385s-1mM-1，这是铁原子弛豫率最高的之一。体内肿瘤成像结果表明了 SPIOs 在临床应用中的潜力。
