Srinivasan A R, Niranjan G, Kuzhandai Velu V, Parmar Pragnesh, Anish A
Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth [SBV] University, Pillaiyarkuppam, Puducherry 607402, India.
Diabetes Metab Syndr. 2012 Oct-Dec;6(4):187-9. doi: 10.1016/j.dsx.2012.09.001. Epub 2012 Oct 18.
Magnesium (Mg) is the fourth most abundant cation in the body and the second most common intracellular cation. The association between hypomagnesemia and insulin resistance (IR) in diabetes mellitus has been documented earlier. However, we wanted to study whether the extracellular status of magnesium (Mg) could be a biochemical mediator between hypertriacylglycerolemia and diabetes mellitus.
To find out the probable association among HbA1c, triacylglycerol (TG) and magnesium levels - a predictor of vascular complications in T(2)DM.
Thirty patients who had attended the diabetic clinics during the period of this study were included. All the samples were analysed for glucose, TG, Mg, and HbA1c. For statistical analysis, SPSS 17 package was used.
Serum TG (236.67*, 195.06) and HbA1C (9.97*, 8.57) levels were independently compared between the two groups and were significantly high in group A subjects (Mg<1.2mg/dl) as compared to group B subjects (Mg>1.2mg/dl) (*p-value<0.05), respectively.
Hypertriacylglycerolemia was pronounced in type 2 diabetes mellitus patients with accompanying hypomagnesemia. This compared well with that of the glycemic control. Low Mg levels, high TG levels in association with enhanced HbA1c levels could thus serve as a reliable biochemical indicator of insulin status and action without resorting to the usage of criteria for insulin sensitivity and resistance.
镁（Mg）是体内第四丰富的阳离子，也是第二常见的细胞内阳离子。低镁血症与糖尿病患者胰岛素抵抗（IR）之间的关联早有记载。然而，我们想研究镁（Mg）的细胞外状态是否可能是高甘油三酯血症与糖尿病之间的生化介质。
找出糖化血红蛋白（HbA1c）、甘油三酯（TG）和镁水平之间可能的关联——2型糖尿病血管并发症的一个预测指标。
纳入本研究期间到糖尿病门诊就诊的30例患者。对所有样本进行葡萄糖、TG、Mg和HbA1c分析。采用SPSS 17软件包进行统计分析。
两组间血清TG（236.67*，195.06）和HbA1C（9.97*，8.57）水平独立比较，A组患者（Mg<1.2mg/dl）明显高于B组患者（Mg>1.2mg/dl）（*p值<0.05）。
伴低镁血症的2型糖尿病患者高甘油三酯血症明显。这与血糖控制情况相符。低Mg水平、高TG水平以及升高的HbA1c水平因此可作为胰岛素状态和作用的可靠生化指标，而无需使用胰岛素敏感性和抵抗标准。
