Kissin C M, Husband J E, Nicholas D, Eversman W
Radiology. 1987 Apr;163(1):67-70. doi: 10.1148/radiology.163.1.3823458.
Serial computed tomographic (CT) scans of 200 patients with malignant testicular teratomas were reviewed. Of the 200 patients, 120 were treated with chemotherapy for metastatic disease; 80 patients with no evidence of metastases (stage I disease) received no treatment and served as a control group. CT was performed at regular intervals for ongoing follow-up in both groups. Thymic enlargement occurred 3-14 months after initiation of treatment in 14 of the 120 patients (11.6%) who received chemotherapy but in only one patient in the control group. Histologic examination in one patient who received chemotherapy revealed that the thymic enlargement represented true hyperplasia. Thirteen of the 14 patients (93%) with thymic enlargement after chemotherapy were well and disease free on mean follow-up of 45 months, compared with 78% of the group that did not show thymic enlargement after chemotherapy (P less than .02). Rebound thymic hyperplasia in adults after chemotherapy for metastatic testicular teratoma may be a good prognostic feature and should be considered when an anterior mediastinal mass develops after chemotherapy for metastatic malignancy.
回顾了200例恶性睾丸畸胎瘤患者的系列计算机断层扫描（CT）图像。200例患者中，120例因转移性疾病接受化疗；80例无转移证据（I期疾病）的患者未接受治疗，作为对照组。两组均定期进行CT检查以持续随访。接受化疗的120例患者中有14例（11.6%）在开始治疗后3至14个月出现胸腺增大，而对照组仅1例出现胸腺增大。对1例接受化疗的患者进行组织学检查显示，胸腺增大为真性增生。化疗后出现胸腺增大的14例患者中有13例（93%）在平均45个月的随访中情况良好且无疾病，而化疗后未出现胸腺增大的患者组这一比例为78%（P<0.02）。转移性睾丸畸胎瘤化疗后成人出现的反弹性胸腺增生可能是一个良好的预后特征，当转移性恶性肿瘤化疗后出现前纵隔肿块时应予以考虑。
