砷暴露与孟加拉国口腔病变。
Arsenic exposure and oral cavity lesions in Bangladesh.
机构信息
Department of Community and Global Health, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
出版信息
J Occup Environ Med. 2013 Jan;55(1):59-66. doi: 10.1097/JOM.0b013e31826bb686.
OBJECTIVE
To evaluate the relationship between arsenic exposure and oral cavity lesions among an arsenic-exposed population in Bangladesh.
METHODS
We carried out an analysis utilizing the baseline data of the Health Effects of Arsenic Exposure Longitudinal Study, which is an ongoing population-based cohort study to investigate health outcomes associated with arsenic exposure via drinking water in Araihazar, Bangladesh. We used multinomial regression models to estimate the risk of oral cavity lesions.
RESULTS
Participants with high urinary arsenic levels (286.1 to 5000.0 μg/g) were more likely to develop arsenical lesions of the gums (multinomial odds ratio = 2.90; 95% confidence interval, 1.11 to 7.54), and tongue (multinomial odds ratio = 2.79; 95% confidence interval, 1.51 to 5.15), compared with those with urinary arsenic levels of 7.0 to 134.0 μg/g.
CONCLUSIONS
Higher level of arsenic exposure was positively associated with increased arsenical lesions of the gums and tongue.
目的
评估孟加拉国砷暴露人群中砷暴露与口腔病变之间的关系。
方法
我们利用正在进行的基于人群的队列研究——孟加拉国 Araihazar 地区饮用水砷暴露相关健康后果的健康效应砷暴露纵向研究的基线数据进行了分析。我们使用多项回归模型来估计口腔病变的风险。
结果
与尿砷水平为 7.0 至 134.0 μg/g 的人相比，尿砷水平较高（286.1 至 5000.0 μg/g）的参与者更易发生牙龈（多项优势比=2.90；95%置信区间，1.11 至 7.54）和舌（多项优势比=2.79；95%置信区间，1.51 至 5.15）砷病变。
结论
较高的砷暴露水平与牙龈和舌的砷病变增加呈正相关。
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