Sanna Vanna, Siddiqui Imtiaz A, Sechi Mario, Mukhtar Hasan
Department of Dermatology, University of Wisconsin, Madison, WI, USA; Department of Chemistry and Pharmacy, Laboratory of Nanomedicine, University of Sassari, Italy.
Department of Dermatology, University of Wisconsin, Madison, WI, USA.
Cancer Lett. 2013 Jun 28;334(1):142-51. doi: 10.1016/j.canlet.2012.11.037. Epub 2012 Nov 29.
There is a need for developing improved therapeutic options for the management of prostate cancer, able to inhibit proliferation of precancerous and malignant lesions and/or to improve the effectiveness of conventional chemopreventive and chemotherapeutic agents. In this perspective, application of nanotechnology based strategies for the delivery of natural compounds for effective management of the disease is being actively researched. Here, after highlighting the most promising natural compounds for chemoprevention and chemotherapy of prostate cancer, the state of the art nanotherapeutics and the recent proof-of-concept of "nanochemoprevention", as well as the clinical development of promising targeted nanoprototypes for use in the prostate cancer treatment are being discussed.
需要开发更好的治疗方案来管理前列腺癌，这些方案应能够抑制癌前病变和恶性病变的增殖，和/或提高传统化学预防和化疗药物的有效性。从这个角度来看，基于纳米技术的策略在递送天然化合物以有效管理该疾病方面的应用正在积极研究中。在此，在强调了用于前列腺癌化学预防和化疗的最有前景的天然化合物之后，将讨论最先进的纳米疗法、“纳米化学预防”的最新概念验证，以及用于前列腺癌治疗的有前景的靶向纳米原型的临床开发情况。
