Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Opt Lett. 2012 Dec 1;37(23):4841-3. doi: 10.1364/OL.37.004841.
To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive proteins, optical fibers are commonly used. However, an optical fiber is limited to delivering light to a single target within the 3D structure of the brain. Here, we describe the design and fabrication of an array of thin microwaveguides, which terminates at a three-dimensionally distributed set of points, appropriate for delivering light to targets distributed in a 3D pattern throughout the brain.
为了将光传递到大脑中以进行神经科学和神经工程学应用，例如光遗传学，其中光被用于激活或沉默表达特定光敏蛋白的神经元，通常使用光纤。然而，光纤仅限于将光传递到大脑 3D 结构内的单个目标。在这里，我们描述了一组薄微波导的设计和制造，其末端是一组三维分布的点，适合将光传递到分布在整个大脑中的 3D 模式中的目标。
