Rocca W A, Bonaiuto S, Lippi A, Luciani P, Turtù F, Cavarzeran F, Amaducci L
Italian Multicentre Study on Dementia, SMID Centre, Florence, Italy.
Neurology. 1990 Apr;40(4):626-31. doi: 10.1212/wnl.40.4.626.
The purpose of this study was to investigate the prevalence of dementia in an Italian population using a door-to-door 2-phase design. As part of a social and health survey, we administered the Hodkinson abbreviated mental test to all persons over age 59 residing in the Commune of Appignano on January 1, 1987 (N = 778). We then investigated all subjects scoring 7 or less on the cognitive test following a standardized diagnostic protocol. We found 48 patients affected by dementia, yielding a crude prevalence ratio (cases per 100 population over age 59) of 6.2; prevalence ratios were 2.6 for Alzheimer's disease, 2.2 for multi-infarct dementia, 0.8 for mixed dementia, 0.4 for secondary dementia, and 0.3 for unspecified dementia. Age- and sex-specific prevalence ratios increased steeply with age and were consistently higher in women for Alzheimer's disease and in men for dementia of all types and multi-infarct dementia. Alzheimer's disease was slightly more frequent than multi-infarct dementia; however, the most common type of dementia varied across age groups. Most cases of Alzheimer's disease were sporadic and had a late age of onset. Comparison with other populations suggests that dementia of all types is as frequent in Appignano as elsewhere, and that Alzheimer's disease might be more frequent in rural than in urban populations.
本研究旨在采用逐户访问的两阶段设计，调查意大利人群中痴呆症的患病率。作为社会与健康调查的一部分，1987年1月1日，我们对居住在阿皮尼亚诺镇的所有59岁以上人员（N = 778）进行了霍金森简易精神测试。随后，我们按照标准化诊断方案，对认知测试得分在7分及以下的所有受试者进行了调查。我们发现48例痴呆症患者，粗患病率（每100名59岁以上人口中的病例数）为6.2；阿尔茨海默病的患病率为2.6，多发性梗死性痴呆为2.2，混合性痴呆为0.8，继发性痴呆为0.4，未特定类型痴呆为0.3。年龄和性别特异性患病率随年龄急剧上升，阿尔茨海默病在女性中始终较高，而所有类型痴呆和多发性梗死性痴呆在男性中始终较高。阿尔茨海默病比多发性梗死性痴呆略常见；然而，最常见的痴呆类型在不同年龄组有所不同。大多数阿尔茨海默病病例为散发性，发病年龄较晚。与其他人群的比较表明，阿皮尼亚诺镇所有类型痴呆的患病率与其他地方一样，且农村地区的阿尔茨海默病患病率可能高于城市地区。
