Coria F, Gomez de Caso J A, Minguez L, Rodriguez-Artalejo F, Claveria L E
Department of Neurology, Segovia General Hospital, Spain.
J Neurol Neurosurg Psychiatry. 1993 Sep;56(9):973-6. doi: 10.1136/jnnp.56.9.973.
To obtain accurate estimates of the prevalence of age-associated memory impairment, dementia, and Alzheimer's disease, a population study was carried out in Turégano, a rural community of 1011 inhabitants in the Segovia province of Spain. The study was divided into two phases: a door to door survey of the entire population aged 40 years and over (503 persons), followed by a clinical examination of suspected cases for positive and differential diagnosis of dementia and cognitive impairment. The prevalence of age-associated memory impairment was 3.6% in individuals of 40 years and over and 7.1% in individuals of 65 years and over, whereas dementia was found in 2.6% and 5.2%, respectively. The prevalence rates of both clinical conditions increased with age. The most prevalent clinical category of dementia was dementia of Alzheimer type, which represented 1.8% and 3.8% of these two age groups. The corresponding figures for vascular dementia were 0.4% and 0.9% and for secondary dementia 0.4% and 0.5%. Age-associated memory impairment is an age-dependent disorder with a high prevalence among the elderly; some of these patients may represent an early stage of Alzheimer's disease, suggesting that the prevalence of this disorder may be higher than previously estimated.
为准确估算与年龄相关的记忆损害、痴呆症和阿尔茨海默病的患病率，在西班牙塞哥维亚省一个有1011名居民的乡村社区图雷加诺开展了一项人群研究。该研究分为两个阶段：对40岁及以上的全体居民（503人）进行逐户调查，随后对疑似病例进行临床检查，以对痴呆症和认知障碍进行阳性和鉴别诊断。40岁及以上人群中与年龄相关的记忆损害患病率为3.6%，65岁及以上人群中为7.1%，而痴呆症的患病率分别为2.6%和5.2%。这两种临床病症的患病率均随年龄增长而上升。痴呆症最常见的临床类型是阿尔茨海默型痴呆症，在这两个年龄组中分别占1.8%和3.8%。血管性痴呆的相应数字为0.4%和0.9%，继发性痴呆为0.4%和0.5%。与年龄相关的记忆损害是一种与年龄相关的疾病，在老年人中患病率较高；其中一些患者可能代表阿尔茨海默病的早期阶段，这表明该疾病的患病率可能高于先前的估计。
