Center for Clinical Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, 6701 Democracy Blvd., Bethesda, MD 20892-4878, USA.
J Am Dent Assoc. 2012 Dec;143(12):1292-302. doi: 10.14219/jada.archive.2012.0090.
Bisphenol A (BPA) and other related chemical compounds may be components used in the manufacturing process of resin-based composite dental restorative material. The purpose of the authors' study was to assess salivary and urinary concentrations of BPA and other compounds before and after placement of resin-based composite dental restorations.
The authors collected saliva and urine from 172 participants receiving composite restorations before and as long as 30 hours after placement of composite restorations. The authors analyzed saliva specimens from 151 participants and urine specimens from 171 participants for concentrations of BPA and five related compounds by using liquid chromatography/mass spectrometry (LC/MS).
Salivary concentrations of BPA and some related compounds increased immediately (within one hour) after composite placement. Salivary concentrations of BPA and most study compounds returned to prerestoration levels within eight hours after composite placement. With the exception of a 43 percent increase in BPA, concentrations of the study compounds in urine returned to prerestoration levels nine to 30 hours after restoration placement. Concentrations in saliva were lower when a rubber dam was used; however, rubber dam use appeared to have no effect on urinary concentrations of the measured compounds during the study period. The authors observed similar changes in study compound levels in both saliva and urine between participants who received anterior restorations and those who received posterior restorations.
Placement of resin-based composite restorations was associated with detectable increases in saliva of BPA and other study compounds within one hour after restoration placement and an increased concentration of BPA in urine nine to 30 hours after restoration placement. Rubber dam use did not reduce the absorption of BPA (measured as BPA level in urine) during the study.
Additional studies are needed to address how long BPA levels in urine associated with composite placement remain elevated to aid in better understanding of the clearance rates of BPA and other study compounds.
双酚 A（BPA）和其他相关化学物质可能是树脂基复合牙科修复材料制造过程中的成分。作者的研究目的是评估在放置树脂基复合牙科修复体前后唾液和尿液中的 BPA 和其他化合物的浓度。
作者收集了 172 名接受复合修复体的参与者的唾液和尿液，分别在放置复合修复体之前和放置后长达 30 小时。作者通过液相色谱/质谱法（LC/MS）分析了 151 名参与者的唾液样本和 171 名参与者的尿液样本中 BPA 和五种相关化合物的浓度。
复合放置后立即（在一小时内）增加了唾液中的 BPA 和一些相关化合物的浓度。放置复合体后八小时内，BPA 和大多数研究化合物的唾液浓度恢复到修复前水平。除 BPA 增加了 43%外，修复后 9 至 30 小时尿液中研究化合物的浓度恢复到修复前水平。使用橡皮障时，BPA 及其他研究化合物的浓度降低；然而，在研究期间，橡皮障的使用似乎对尿液中测量化合物的浓度没有影响。作者在接受前牙修复和后牙修复的参与者的唾液和尿液中均观察到研究化合物水平的类似变化。
放置树脂基复合修复体后，在修复后一小时内唾液中可检测到 BPA 和其他研究化合物的浓度增加，在修复后 9 至 30 小时内尿液中 BPA 的浓度增加。在研究期间，使用橡皮障并没有减少 BPA（以尿液中 BPA 水平来衡量）的吸收。
需要进一步研究以确定与复合放置相关的尿液中 BPA 水平升高持续多长时间，以帮助更好地了解 BPA 和其他研究化合物的清除率。
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