Gussander E, Adams A
J Gen Virol. 1979 Nov;45(2):331-40. doi: 10.1099/0022-1317-45-2-331.
The physical state of the Epstein-Barr virus (EBV) DNA in three cell lines which spontaneously produce virus has been characterized. Circular EBV DNA molecules have been found in P3HR-I, B95-8 and M8I cells. The size of the intracellular M8I circular EBV DNA molecules is comparable with the linear virus genome isolated from virus particles but the circular P3HR-I and B95-8 DNA molecules are shorter than the virion DNA . In addition to the circular form, some EBV DNA with physical properties indicative of integrated sequences was found in all three producer cell lines. There was no marked change in the amount of either the circular or integrated forms of EBV DNA when these producer cell lines were grown in the presence of phosphonacetic acid to suppress the spontaneous virus production which occurs in a small percentage of the cells in untreated cultures.
对三种能自发产生病毒的细胞系中EB病毒（EBV）DNA的物理状态进行了表征。在P3HR - I、B95 - 8和M8I细胞中发现了环状EBV DNA分子。细胞内M8I环状EBV DNA分子的大小与从病毒颗粒中分离出的线性病毒基因组相当，但环状P3HR - I和B95 - 8 DNA分子比病毒体DNA短。除了环状形式外，在所有三种产生病毒的细胞系中都发现了一些具有整合序列物理特性的EBV DNA。当这些产生病毒的细胞系在膦乙酸存在下生长以抑制未处理培养物中一小部分细胞中发生的自发病毒产生时，EBV DNA的环状或整合形式的量没有明显变化。
