Tabung Fred, Steck Susan E, Su L Joseph, Mohler James L, Fontham Elizabeth T H, Bensen Jeannette T, Hebert James R, Zhang Hongmei, Arab Lenore
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA ; Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
Prostate Cancer. 2012;2012:323296. doi: 10.1155/2012/323296. Epub 2012 Nov 13.
Purpose. To examine the associations among intake of refined grains, whole grains and dietary fiber and aggressiveness of prostate cancer in African Americans (AA, n = 930) and European Americans (EA, n = 993) in a population-based, case-only study (The North Carolina-Louisiana Prostate Cancer Project, PCaP). Methods. Prostate cancer aggressiveness was categorized as high, intermediate or low based on Gleason grade, PSA level and clinical stage. Dietary intake was assessed utilizing the NCI Diet History Questionnaire. Logistic regression (comparing high to intermediate/low aggressive cancers) and polytomous regression with adjustment for potential confounders were used to determine odds of high prostate cancer aggressiveness with intake of refined grains, whole grains and dietary fiber from all sources. Results. An inverse association with aggressive prostate cancer was observed in the 2nd and 3rd tertiles of total fiber intake (OR = 0.70; 95% CI, 0.50-0.97 and OR = 0.61; 95% CI, 0.40-0.93, resp.) as compared to the lowest tertile of intake. In the race-stratified analyses, inverse associations were observed in the 3rd tertile of total fiber intake for EA (OR = 0.44; 95% CI, 0.23-0.87) and the 2nd tertile of intake for AA (OR = 0.57; 95% CI, 0.35-0.95). Conclusions. Dietary fiber intake was inversely associated with aggressive prostate cancer among both AA and EA men.
目的。在一项基于人群的病例对照研究（北卡罗来纳州 - 路易斯安那州前列腺癌项目，PCaP）中，研究非裔美国人（AA，n = 930）和欧裔美国人（EA，n = 993）精制谷物、全谷物及膳食纤维摄入量与前列腺癌侵袭性之间的关联。方法。根据 Gleason 分级、前列腺特异抗原（PSA）水平及临床分期，将前列腺癌侵袭性分为高、中、低三类。采用美国国立癌症研究所饮食史问卷评估饮食摄入量。运用逻辑回归（比较高侵袭性与中/低侵袭性癌症）及多分类回归，并对潜在混杂因素进行校正，以确定摄入精制谷物、全谷物及所有来源膳食纤维时前列腺癌高侵袭性的比值比。结果。与总膳食纤维摄入量最低三分位数相比，在总膳食纤维摄入量的第二和第三三分位数中观察到与侵袭性前列腺癌呈负相关（比值比分别为 0.70；95%置信区间，0.50 - 0.97 和 0.61；95%置信区间，0.40 - 0.93）。在按种族分层的分析中，对于欧裔美国人，在总膳食纤维摄入量第三三分位数中观察到负相关（比值比 = 0.44；95%置信区间，0.23 - 0.87）；对于非裔美国人，在摄入量第二三分位数中观察到负相关（比值比 = 0.57；95%置信区间，0.35 - 0.95）。结论。非裔美国人和欧裔美国男性中，膳食纤维摄入量与侵袭性前列腺癌均呈负相关。
