Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
ACS Nano. 2012 Dec 21;6(12):10438-48. doi: 10.1021/nn3052499. Epub 2012 Dec 7.
Nanoengineered particles that can facilitate drug formulation and improve specificity of delivery afford exciting opportunities for improved lesion-specific therapy. Understanding and controlling the nano-bio interactions of these materials is central to future developments in this area. Mass-spectrometry-based proteomics techniques, in conjunction with other emerging technologies, are enabling novel insights into the modulation of particle surfaces by biological fluids (formation of the protein corona) and subsequent particle-induced cellular responses. In this Perspective, we summarize important recent developments using proteomics-based techniques to understand nano-bio interactions and discuss the impact of such knowledge on improving particle design.
纳米工程颗粒可以促进药物制剂的形成，并提高药物传递的特异性，为改善病变特异性治疗提供了令人兴奋的机会。了解和控制这些材料的纳米 - 生物相互作用是该领域未来发展的核心。基于质谱的蛋白质组学技术与其他新兴技术相结合，使人们能够深入了解生物流体对颗粒表面的调节（形成蛋白质冠）以及随后的颗粒诱导的细胞反应。在本观点中，我们总结了使用基于蛋白质组学的技术来理解纳米 - 生物相互作用的重要最新进展，并讨论了这种知识对改进颗粒设计的影响。
