Laub M, Sjøgren P, Holm-Knudsen R, Flachs H, Christiansen E
Department of Anaesthesia, Gentofte Hospital, University of Copenhagen, Denmark.
Anaesthesia. 1990 Feb;45(2):110-2. doi: 10.1111/j.1365-2044.1990.tb14272.x.
The efficacy of the lytic cocktail (1 ml contains pethidine 28 mg, promethazine 7 mg, chlorpromazine 7 mg) administered intramuscularly or rectally as premedication was studied in 51 children aged 1-12 years who had minor elective otological surgery. One group received 0.05 ml/kg intramuscularly (maximum dose 2.0 ml) and the other 0.07 ml/kg per rectum (maximum dose 2.8 ml). Most were satisfactorily sedated before operation, but after operation the rectally premedicated children were less sedated, which was in agreement with lower plasma pethidine concentrations in this group. The rectal dose should be increased if prolonged postoperative sedation is desireable.
对51名年龄在1至12岁、接受小型择期耳科手术的儿童，研究了作为术前用药经肌肉注射或直肠给药的溶菌鸡尾酒（1毫升含哌替啶28毫克、异丙嗪7毫克、氯丙嗪7毫克）的疗效。一组肌肉注射0.05毫升/千克（最大剂量2.0毫升），另一组经直肠给药0.07毫升/千克（最大剂量2.8毫升）。大多数儿童在手术前镇静效果良好，但术后经直肠术前用药的儿童镇静程度较低，这与该组较低的血浆哌替啶浓度一致。如果希望术后有较长时间的镇静作用，直肠给药剂量应增加。
