Laboratory of Sericulture and Entomoresources, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
Virology. 2013 Jan 5;435(1):1-13. doi: 10.1016/j.virol.2012.10.016.
Innate immunity is essential for insects to survive infectious pathogens. In baculovirus-infected lepidopteran cells, apoptosis and global protein synthesis shutdown are major mechanisms of intracellular innate immunity that inhibit viral replication. In contrast, baculoviruses have evolved diverse genes and mechanisms to counter the antiviral immunity activated in infected cells. In this review, we summarize the current knowledge of the cellular antiviral pathways and the baculovirus genes that modulate antiviral immunity. The studies highlighted illustrate a high degree of diversity in both the cellular responses against viral infections and viral responses against intracellular antiviral immunity, providing an important basis of further studies in this field.
先天免疫对于昆虫存活于传染性病原体是至关重要的。在杆状病毒感染的鳞翅目细胞中，细胞凋亡和全局蛋白质合成关闭是抑制病毒复制的细胞内先天免疫的主要机制。相比之下，杆状病毒已经进化出多种基因和机制来对抗感染细胞中激活的抗病毒免疫。在这篇综述中，我们总结了细胞抗病毒途径和杆状病毒基因调节抗病毒免疫的最新知识。强调的研究说明了针对病毒感染的细胞反应和针对细胞内抗病毒免疫的病毒反应具有高度的多样性，为该领域的进一步研究提供了重要基础。
