新疆阿魏（Ferula ferulaeoides （Steud.）Korov.）中的倍半萜类衍生物

Sesquiterpenoid derivatives from Ferula ferulaeoides (Steud.) Korov.

机构信息

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.

出版信息

Phytochemistry. 2013 Feb;86:151-8. doi: 10.1016/j.phytochem.2012.10.013. Epub 2012 Dec 3.

DOI:10.1016/j.phytochem.2012.10.013

Abstract

Eight sesquiterpenoids, named Ferulaeone A-H (1-8), and seven known sesquiterpenoid derivatives were isolated from the roots of Ferula ferulaeoides (Steud.) Korov. Their structures were established by comprehensive spectroscopic analysis, and biosynthetic pathways leading to these compounds were proposed. The cytotoxicity of all these isolates against HepG2, MCF-7, and C6 cancer cell lines was evaluated and compounds 6-11, 13 exihibited various degrees of cytotoxic effect. Among them, compounds 9-11 displayed the highest potency against C6 with IC(50) values 34, 36, and 31 μM, respectively.

摘要

从 Ferula ferulaeoides（Steud.）Korov 的根部分离得到了 8 种倍半萜类化合物，命名为 Ferulaeone A-H（1-8），以及 7 种已知的倍半萜类衍生物。通过综合光谱分析确定了它们的结构，并提出了这些化合物的生物合成途径。对所有这些分离物对 HepG2、MCF-7 和 C6 癌细胞系的细胞毒性进行了评估，化合物 6-11、13 表现出不同程度的细胞毒性作用。其中，化合物 9-11 对 C6 的活性最高，IC（50）值分别为 34、36 和 31 μM。