Sozmen M, Kabak Y B, Gulbahar M Y, Gacar A, Karayigit M O, Guvenc T, Yarim M
Department of Pathology, Faculty of Veterinary Medicine, Ondokuz Mayis University, TR-55139 Samsun, Turkey.
J Comp Pathol. 2013 Jul;149(1):10-8. doi: 10.1016/j.jcpa.2012.09.010. Epub 2012 Dec 6.
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Recent studies have demonstrated that PPARs regulate lipid metabolism and are expressed in various cancers. The aim of the present study was to investigate the expression of PPAR-α, -β and -γ in normal canine testicular tissue and canine testicular tumours (CTTs). Expression of PPAR-α, -β and -γ was greater (P <0.05) than in normal testicular tissue. PPARs were therefore induced in CTTs and they may play a role in the biology of these tumours.
过氧化物酶体增殖物激活受体（PPARs）是属于核激素受体超家族的配体激活转录因子。最近的研究表明，PPARs调节脂质代谢并在多种癌症中表达。本研究的目的是调查PPAR-α、-β和-γ在正常犬睾丸组织和犬睾丸肿瘤（CTTs）中的表达。PPAR-α、-β和-γ的表达高于正常睾丸组织（P<0.05）。因此，CTTs中诱导了PPARs，它们可能在这些肿瘤的生物学过程中发挥作用。
