DNA 结构诱导遗传不稳定性的修复机制的阴阳两面。
The yin and yang of repair mechanisms in DNA structure-induced genetic instability.
机构信息
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd. R1800, Austin, TX 78723, United States.
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd. R1800, Austin, TX 78723, United States.
出版信息
Mutat Res. 2013 Mar-Apr;743-744:118-131. doi: 10.1016/j.mrfmmm.2012.11.005. Epub 2012 Dec 3.
DNA can adopt a variety of secondary structures that deviate from the canonical Watson-Crick B-DNA form. More than 10 types of non-canonical or non-B DNA secondary structures have been characterized, and the sequences that have the capacity to adopt such structures are very abundant in the human genome. Non-B DNA structures have been implicated in many important biological processes and can serve as sources of genetic instability, implicating them in disease and evolution. Non-B DNA conformations interact with a wide variety of proteins involved in replication, transcription, DNA repair, and chromatin architectural regulation. In this review, we will focus on the interactions of DNA repair proteins with non-B DNA and their roles in genetic instability, as the proteins and DNA involved in such interactions may represent plausible targets for selective therapeutic intervention.
DNA 可以采用多种偏离经典沃森-克里克 B-DNA 形式的二级结构。已经鉴定出超过 10 种非规范或非 B DNA 二级结构，并且具有采用这种结构能力的序列在人类基因组中非常丰富。非 B DNA 结构与许多重要的生物过程有关，并可作为遗传不稳定性的来源，这使它们与疾病和进化有关。非 B DNA 构象与涉及复制、转录、DNA 修复和染色质结构调节的多种蛋白质相互作用。在这篇综述中，我们将重点关注 DNA 修复蛋白与非 B DNA 的相互作用及其在遗传不稳定性中的作用，因为参与这种相互作用的蛋白质和 DNA 可能代表选择性治疗干预的合理靶点。
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