替代性DNA结构对DNA损伤、DNA修复和基因不稳定性的影响。
Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability.
作者信息
Wang Guliang, Vasquez Karen M
机构信息
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd. R1800, Austin, TX 78723, United States.
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd. R1800, Austin, TX 78723, United States.
出版信息
DNA Repair (Amst). 2014 Jul;19:143-51. doi: 10.1016/j.dnarep.2014.03.017. Epub 2014 Apr 21.
Abstract
Repetitive genomic sequences can adopt a number of alternative DNA structures that differ from the canonical B-form duplex (i.e. non-B DNA). These non-B DNA-forming sequences have been shown to have many important biological functions related to DNA metabolic processes; for example, they may have regulatory roles in DNA transcription and replication. In addition to these regulatory functions, non-B DNA can stimulate genetic instability in the presence or absence of DNA damage, via replication-dependent and/or replication-independent pathways. This review focuses on the interactions of non-B DNA conformations with DNA repair proteins and how these interactions impact genetic instability.
摘要
重复基因组序列可以呈现多种不同于经典B型双链体的替代DNA结构（即非B型DNA）。这些形成非B型DNA的序列已被证明具有许多与DNA代谢过程相关的重要生物学功能；例如，它们可能在DNA转录和复制中具有调控作用。除了这些调控功能外，非B型DNA在存在或不存在DNA损伤的情况下，可通过依赖复制和/或不依赖复制的途径刺激遗传不稳定性。本综述重点关注非B型DNA构象与DNA修复蛋白的相互作用，以及这些相互作用如何影响遗传不稳定性。
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