Gruner S, Diezel W, Strunk D, Zwirner A, Sönnichsen N, Anhalt G J
Department of Dermatology (Charité Hospital) Humboldt University, Berlin, GDR.
Arch Dermatol Res. 1990;281(8):526-9. doi: 10.1007/BF00412738.
Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin deprived of these cells. A high dose of cyclophosphamide or dexamethasone led to a drastic decrease of LC density in murine skin with slow and incomplete restoration. SP-5 accelerated Langerhans cell recruitment and led to pretreatment levels of Langerhans cell density in the skin. These results indicate that SP-5 may possibly be used to treat disorders (e.g., HIV infection) where impaired Langerhans cell density and function can lead to secondary cutaneous infections.
脾五肽（SP-5：精氨酸-赖氨酸-谷氨酸-缬氨酸-酪氨酸），一种与脾脏激素脾素的32-36位残基相对应的五肽，能剂量依赖性地增加骨髓集落（M集落和GM集落）的数量。因此，我们测试了SP-5对缺乏这些细胞的皮肤中表皮朗格汉斯细胞募集的刺激作用。高剂量的环磷酰胺或地塞米松导致小鼠皮肤中朗格汉斯细胞密度急剧下降，恢复缓慢且不完全。SP-5加速了朗格汉斯细胞的募集，并使皮肤中朗格汉斯细胞密度达到预处理水平。这些结果表明，SP-5可能可用于治疗朗格汉斯细胞密度和功能受损可导致继发性皮肤感染的疾病（如HIV感染）。
