Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig AöR, Germany.
Eur J Dermatol. 2012 Nov-Dec;22(6):751-7. doi: 10.1684/ejd.2012.1865.
There is evidence that chronic inflammation due to bacterial wound colonization delays wound healing.
In this study, in a Leipzig (Germany) cohort of chronic wound patients, the microbiological spectrum in 2005 and in 2010 was evaluated, as were patients with continuous ulceration sequentially over a decade from 2001-2011.
We retrospectively analysed the microbial swabs of 126 patients with chronic leg ulcers caused by chronic venous insufficiency.
In the cross-sectional analysis in both 2005 and 2010, as well as in the longitudinal analysis, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis and Enterococcus faecalis were respectively the most common pathogens colonizing chronic leg ulcers. In the longitudinal analysis from 2001-2011, the same bacterial species could be identified ≥ 3 years consecutively in 20/35 patients. Normally only one or two species could persistently be demonstrated over the years. The subgroup of patients with ≥ 3 x confirmation of P. aeruginosa in their swabs showed a longer wound duration compared to all patients in the longitudinal group.
We registered the persistence of bacteria like P. aeruginosa or S. aureus in consecutive bacterial swabs over the years in individual patients with non-healing venous ulcerations.
有证据表明，细菌定植引起的慢性炎症会延迟伤口愈合。
本研究对莱比锡（德国）慢性伤口患者队列 2005 年和 2010 年的微生物谱进行了评估，并对 2001 年至 2011 年连续 10 年溃疡持续的患者进行了分析。
我们回顾性分析了 126 例由慢性静脉功能不全引起的慢性腿部溃疡患者的微生物拭子。
在 2005 年和 2010 年的横断面分析以及 2001-2011 年的纵向分析中，金黄色葡萄球菌、铜绿假单胞菌、奇异变形杆菌和粪肠球菌分别是最常见的定植于慢性腿部溃疡的病原体。在 2001-2011 年的纵向分析中，35 例患者中有 20 例连续 3 年以上可检测到相同的细菌。通常情况下，多年来只能持续检测到一种或两种细菌。在纵向组的所有患者中，与所有患者相比，在其拭子中确认存在铜绿假单胞菌≥3 次的患者的伤口持续时间更长。
我们在多年的连续细菌拭子中记录了像铜绿假单胞菌或金黄色葡萄球菌这样的细菌在非愈合性静脉溃疡患者中的持续存在。
