Wolz Michael M, Camilleri Michael J, McEvoy Marian T, Bruce Alison J
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Am J Dermatopathol. 2013 May;35(3):e53-6. doi: 10.1097/DAD.0b013e318278d419.
Pyodermatitis-pyostomatitis vegetans (PPV) constitutes an inflammatory mucocutaneous dermatosis that is associated with inflammatory bowel disease. Clinically, PPV appears as pustules on mucosal surfaces and as vegetating exudative plaques on intertriginous surfaces. It is typically a clinical diagnosis supported by histological findings. Microscopic findings include epidermal hyperplasia, focal acantholysis, and a dense mixed inflammatory infiltrate with intraepithelial and subepithelial eosinophilic microabscesses. In the recent literature, immunofluorescence has been thought to be negative in PPV or, if positive, an aberrant finding. Herein, we report 2 cases of PPV associated with inflammatory bowel disease, which display intercellular IgA deposits. Although these cases may represent isolated epiphenomena, it is possible that the paucity of PPV cases with immunofluorescent studies hitherto has led to an oversight of an interesting association between intercellular IgA and PPV.
增殖性脓皮病-增殖性口炎（PPV）是一种与炎症性肠病相关的炎症性黏膜皮肤疾病。临床上，PPV表现为黏膜表面的脓疱以及褶皱部位的增殖性渗出性斑块。它通常是一种由组织学结果支持的临床诊断。显微镜下表现包括表皮增生、局灶性棘层松解，以及伴有上皮内和上皮下嗜酸性微脓肿的密集混合性炎症浸润。在最近的文献中，免疫荧光在PPV中被认为是阴性的，或者即使呈阳性，也是一种异常发现。在此，我们报告2例与炎症性肠病相关的PPV病例，其显示细胞间IgA沉积。尽管这些病例可能代表孤立的附带现象，但迄今为止PPV病例免疫荧光研究的缺乏可能导致了对细胞间IgA与PPV之间有趣关联的忽视。
