通过铜催化的交叉偶联反应高区域选择性合成稠合的七元环。
Highly regioselective synthesis of fused seven-membered rings through copper-catalyzed cross-coupling.
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
出版信息
Chem Commun (Camb). 2013 Jan 25;49(7):701-3. doi: 10.1039/c2cc37891d.
PMID:23223387
Abstract
A highly efficient protocol of copper catalysis for the one-pot synthesis of fused dibenzo[b,f][1,4]oxazepines is reported. The transformation involves a Smiles rearrangement, leading to the completely different regioselectivity from the classical cross-coupling. The easy reaction of aryl chlorides as substrates enhances the practical application of the methodology.
摘要
报道了一种高效的铜催化一锅法合成稠合二苯并[b,f][1,4]氧氮杂卓的方法。该转化涉及 Smiles 重排，导致与经典交叉偶联完全不同的区域选择性。芳基氯化物作为底物的易反应性增强了该方法的实际应用。
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