MRC Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
Rev Endocr Metab Disord. 2012 Dec;13(4):253-63. doi: 10.1007/s11154-012-9228-2.
The ovarian steroid hormones progesterone and estradiol are well established regulators of human endometrial function. However, more recent evidence suggests that androgens and locally generated steroids, such as the glucocorticoids, also have a significant impact on endometrial breakdown and repair. The temporal and spatial pattern of steroid receptor presence in endometrial cells has a significant impact on the endometrial response to steroids. Furthermore, regulation of steroid receptor function by modulatory proteins further refines local responses. This review focuses on steroid regulation of endometrial function during the luteo-follicular transition with a focus on menstruation and endometrial repair.
卵巢甾体激素孕酮和雌二醇是人类子宫内膜功能的重要调节剂。然而，最近的证据表明，雄激素和局部产生的类固醇，如糖皮质激素，也对子宫内膜的崩解和修复有重大影响。甾体激素受体在子宫内膜细胞中的存在的时空模式对子宫内膜对甾体激素的反应有重大影响。此外，调节蛋白对甾体激素受体功能的调节进一步细化了局部反应。本综述重点介绍黄体-卵泡过渡期甾体激素对子宫内膜功能的调节，特别关注月经和子宫内膜修复。
