Department of Ophthalmology, University of Kinshasa, Kinshasa, The Republic of Congo.
PLoS One. 2012;7(12):e49411. doi: 10.1371/journal.pone.0049411. Epub 2012 Dec 3.
To estimate the prevalence of DR and to correlate cardiometabolic, sociodemographic, and oxidant/antioxidant imbalance data to the prevalence of DR.
This case-control study included type 2 DM (T2 DM) patients with DR (n = 66), T2 DM patients without DR (N = 84), and healthy controls (n = 45) without DR, in Kinshasa town. Diet, albuminemia, serum vitamins, and 8-isoprostane were examined.
No intake of safou (OR = 2.7 95% CI 1.2-5.8; P = 0.014), low serum albumin <4.5 g/dL (OR-2.9 95% CI 1.4-5.9; P = 0.003), no intake of fumbwa (OR = 2.8 95% CI 1.2-6.5; P = 0.014), high 8-isoprostane (OR = 14.3 95% CI 4.5-46; P<0.0001), DM duration ≥ 5 years (OR = 3.8 95% CI 1.6-9.1; P = 0.003), and low serum vitamin C (OR = 4.5 95% CI 1.3-15.5; P = 0.016) were identified as the significant independent determinants of DR.
The important role of oxidant/antioxidant status imbalance and diet is demonstrated in DR.
评估糖尿病视网膜病变（DR）的患病率，并将心血管代谢、社会人口学和氧化/抗氧化失衡数据与 DR 的患病率相关联。
本病例对照研究纳入了来自金沙萨镇的 2 型糖尿病（T2DM）伴 DR 患者（n=66）、T2DM 无 DR 患者（N=84）和无 DR 的健康对照者（n=45）。检查了饮食、白蛋白血症、血清维生素和 8-异前列腺素。
未摄入 safou（OR=2.7 95%CI 1.2-5.8；P=0.014）、血清白蛋白<4.5g/dL（OR=-2.9 95%CI 1.4-5.9；P=0.003）、未摄入 fumbwa（OR=2.8 95%CI 1.2-6.5；P=0.014）、高 8-异前列腺素（OR=14.3 95%CI 4.5-46；P<0.0001）、DM 病程≥5 年（OR=3.8 95%CI 1.6-9.1；P=0.003）和血清维生素 C 水平低（OR=4.5 95%CI 1.3-15.5；P=0.016）是 DR 的显著独立决定因素。
氧化/抗氧化失衡和饮食在 DR 中起重要作用。
