基于模型人群分析筛选淫羊藿中治疗骨质疏松症的生物活性成分
[Screening of bioactive components in epimedium for osteoporosis treatment by model population analysis].
作者信息
Yang Qian-Xu, Liu Yan-Qiu, Wang Li, Xiao Hong-Bin
机构信息
Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
出版信息
Yao Xue Xue Bao. 2012 Sep;47(9):1205-9.
Epimedium was obtained from different habitats, and their bioactive components for inhibiting RAW264.7 were screened by MTT assay. Results indicate that epimedium from different habitats displayed significant different activities. By means of model population analysis (MPA), a latent bioactive component, baohuoside-I was got. Activity of baohuoside-I wasvalidated and prior to icariin. MPA can be used for bioactive components screening.
淫羊藿取自不同产地，通过MTT法筛选其抑制RAW264.7细胞的生物活性成分。结果表明，不同产地的淫羊藿表现出显著不同的活性。通过模型种群分析（MPA），得到一种潜在的生物活性成分——宝藿苷-I。宝藿苷-I的活性得到验证且优于淫羊藿苷。MPA可用于生物活性成分的筛选。
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