Resident of Endodontics, Hamedan University of medical sciences, Hamedan, Iran.
Med Oral Patol Oral Cir Bucal. 2013 Mar 1;18(2):e351-5. doi: 10.4317/medoral.18465.
The purpose of this study was to investigate the effect of pregnancy on orthodontic tooth movement in Wistar rats.
Forty eight female three-month old Wistar rats with an average weight of 250 ± 25 gr were selected and randomly divided into two experimental (pregnant) and control groups (non-pregnant). Maxillary central incisors were tipped distally by insertion of springs exerting 30 g force. Two, seven and fourteen days after spring insertion animals were sacrificed. Then the mesioincisal distance between maxillary incisors were measured. Subsequently, histological sections were prepared to count osteoclasts under a light microscope. The data on the extent of orthodontic tooth movement, and the number of osteoclasts were analyzed by independent sample t-test.
The results indicated that 2,7 and 14 days after force application there was no significant difference in orthodontic tooth movement between experimental and control groups (p>0.05). The number of osteoclasts were significantly lower in the experimental group 7 and 14 days after spring insertion (p<0.05).
Pregnancy may decrease the amount of tooth movement in the linear phase but it is not statistically significant. The number of osteoclasts is significantly decreased during pregnancy.
本研究旨在探讨妊娠对 Wistar 大鼠正畸牙移动的影响。
选择 48 只 3 月龄、平均体重 250±25g 的雌性 Wistar 大鼠，随机分为两组：实验组（妊娠）和对照组（非妊娠）。通过插入施力 30g 的弹簧，使上颌中切牙远中倾斜。在弹簧插入后第 2、7、14 天，处死动物。然后测量上颌切牙的近中切牙距离。随后，在光镜下制备组织学切片，以计数破骨细胞。通过独立样本 t 检验分析正畸牙移动程度和破骨细胞数量的数据。
结果表明，在力施加后第 2、7 和 14 天，实验组和对照组之间的正畸牙移动无显著差异（p>0.05）。实验组在弹簧插入后第 7 和 14 天破骨细胞数量明显减少（p<0.05）。
妊娠可能会减少线性阶段的牙齿移动量，但无统计学意义。妊娠期间破骨细胞数量明显减少。
