UCLA Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, Los Angeles, CA, United States.
Schizophr Res. 2013 Feb;143(2-3):307-11. doi: 10.1016/j.schres.2012.10.043. Epub 2012 Dec 9.
Neurocognition in general, and memory functioning in particular, as well as symptoms have all been shown to be related to social problem solving (SPS) in schizophrenia. However, few studies have directly compared the relative contribution of neurocognition vs. psychiatric symptoms to the components of SPS.
Sixty outpatients (aged 21-65) who met DSM-IV criteria for schizophrenia or schizoaffective disorder were administered a broad battery of memory tests and assessed for severity of positive and negative symptoms as part of a baseline assessment of a study of psychiatric rehabilitation. Multiple regression analyses were used to examine the contribution of memory functioning vs. symptoms on receiving, processing, and sending skill areas of social problem solving ability.
An index of verbal learning was the strongest predictor of processing skills whereas negative symptoms were the strongest predictor of sending skills. Positive symptoms were not related to any of the three skill areas of social problem solving.
Memory functioning and psychiatric symptoms differentially predict selected areas of social problem solving ability in persons with schizophrenia. Consistent with other reports, positive symptoms were not related to social problem solving. Consideration of both neurocognition and negative symptoms may be important to the development of rehabilitation interventions in this area of functioning.
神经认知功能，尤其是记忆功能，以及症状，都与精神分裂症患者的社会问题解决能力（SPS）有关。然而，很少有研究直接比较神经认知功能与精神病症状对 SPS 各组成部分的相对贡献。
60 名符合 DSM-IV 精神分裂症或分裂情感障碍标准的门诊患者（年龄 21-65 岁）接受了广泛的记忆测试，并评估了阳性和阴性症状的严重程度，作为精神康复研究基线评估的一部分。采用多元回归分析来检验记忆功能与症状对社会问题解决能力的接受、处理和发送技能领域的贡献。
言语学习指数是处理技能的最强预测因子，而阴性症状是发送技能的最强预测因子。阳性症状与社会问题解决的三个技能领域均无关。
记忆功能和精神病症状可不同程度地预测精神分裂症患者社会问题解决能力的特定领域。与其他报告一致，阳性症状与社会问题解决无关。考虑到神经认知功能和阴性症状，可能对该功能领域的康复干预的发展很重要。
