Ohshima Y, Schumacher-Perdreau F, Peters G, Quie P G, Pulverer G
Institute of Medical Microbiology and Hygiene, University of Cologne, Federal Republic of Germany.
Infect Immun. 1990 May;58(5):1350-4. doi: 10.1128/iai.58.5.1350-1354.1990.
An encapsulated strain of Staphylococcus simulans was observed to be more resistant to phagocytosis by human granulocytes than was a nonencapsulated strain. Phagocytosis of the encapsulated strain was enhanced by antisera to S. simulans, but opsonic activity of antisera was removed by absorption with S. simulans capsular material. The encapsulated strain of S. simulans was also more invasive than the nonencapsulated S. simulans in vivo. More encapsulated than nonencapsulated S. simulans were found in heart blood when equal numbers of organisms were injected intraperitoneally into mice. Invasion of the bloodstreams of mice by encapsulated S. simulans was prevented by passive immunization (rabbit antiserum). Thus, the capsule of S. simulans inhibited phagocytosis in vitro and contributed to virulence in vivo.
观察到一株包膜化的模仿葡萄球菌比一株非包膜化的菌株对人粒细胞的吞噬作用更具抗性。针对模仿葡萄球菌的抗血清可增强对包膜化菌株的吞噬作用，但抗血清的调理活性可通过用模仿葡萄球菌荚膜物质吸收而去除。在体内，包膜化的模仿葡萄球菌菌株也比非包膜化的模仿葡萄球菌更具侵袭性。当将等量的细菌腹腔注射到小鼠体内时，在心脏血液中发现的包膜化模仿葡萄球菌比非包膜化的更多。被动免疫（兔抗血清）可阻止包膜化的模仿葡萄球菌侵入小鼠的血流。因此，模仿葡萄球菌的荚膜在体外抑制吞噬作用，并在体内有助于毒力。
