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骨髓移植后致命性表皮葡萄球菌败血症

Fatal Staphylococcus epidermidis sepsis following bone marrow transplantation.

作者信息

Bender J W, Hughes W T

出版信息

Johns Hopkins Med J. 1980 Jan;146(1):13-5.

PMID:6986499
Abstract

Staphylococcus epidermidis septicemia and pneumonia developed in an 18-year-old male undergoing bone marrow transplantation. The organism was isolated from multiple blood cultures, sputum cultures, an indwelling catheter tip and post-mortem lung biopsy specimens. The bacterium was resistant to penicillin, erythromycin, clindamycin, chloramphenicol, vancomycin, gentamicin, cephalothin and trimethoprim-sulfamethoxazole, but was sensitive to rifampin. The rapid demise of this patient, as well as the difficulty in achieving effective antibiotic therapy, illustrates the potential pathogenicity of this organism in immunosuppressed patients.

摘要

一名接受骨髓移植的18岁男性发生了表皮葡萄球菌败血症和肺炎。该病原体从多份血培养、痰培养、一根留置导管尖端以及尸检肺活检标本中分离出来。该细菌对青霉素、红霉素、克林霉素、氯霉素、万古霉素、庆大霉素、头孢噻吩和甲氧苄啶-磺胺甲恶唑耐药,但对利福平敏感。该患者的迅速死亡以及难以实现有效的抗生素治疗,说明了这种病原体在免疫抑制患者中的潜在致病性。

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Invasive infections with a coagulase-negative staphylococcus in an immunocompromised patient: case report and review of the literature.
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Ann Hematol. 2008 Sep;87(9):771-2. doi: 10.1007/s00277-008-0476-x. Epub 2008 Apr 3.
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