Department of Microbiology, School of Medicine, University of Patras, Patras, Greece.
J Clin Microbiol. 2013 Feb;51(2):665-8. doi: 10.1128/JCM.03071-12. Epub 2012 Dec 12.
An outbreak of multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections in a university hospital is described. Phenotypic and genotypic analysis of 240 isolates revealed that 152 patients, mainly in the intensive care unit (ICU), were colonized or infected with MDRPA, the majority with O11. All metallo-β-lactamase (MBL)-positive isolates carried the bla(VIM-2) or bla(VIM-1) gene. One or more type III secretion system toxin genes were detected in most isolates. Five dominant pulsed-field gel electrophoresis (PFGE) types were characterized, associated with ST235, ST111, ST253, ST309, and ST639.
本文描述了一起大学医院发生的多重耐药铜绿假单胞菌(MDRPA)感染爆发事件。对 240 株分离株的表型和基因型分析显示,152 名主要在重症监护病房(ICU)的患者发生了 MDRPA 定植或感染,其中大多数为 O11 型。所有产金属β-内酰胺酶(MBL)的分离株均携带 bla(VIM-2)或 bla(VIM-1)基因。大多数分离株中检测到一个或多个 III 型分泌系统毒素基因。5 种主要的脉冲场凝胶电泳(PFGE)类型与 ST235、ST111、ST253、ST309 和 ST639 相关。