Yuzhalin Arseniy E, Kutikhin Anton G
Research Institute for Complex Issues of Cardiovascular Diseases under Siberian Branch of Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
Asian Pac J Cancer Prev. 2012;13(10):5091-6. doi: 10.7314/apjcp.2012.13.10.5091.
There is a large amount of evidence that the ABO blood group system may play a role in disease etiology. A relationship between ABO and Rhesus blood groups and cancer risk has been demonstrated in a number of studies. However, in relation to gynecological malignancies, these findings are inconsistent and contradictory.
To perform a case-control study for analysis of the distribution of ABO and Rh blood antigens among women from South-East Siberia who suffered from ovarian, endometrial and cervical cancer, and to assess the potential role of these antigens in carcinogenesis.
DESIGN, SUBJECTS AND METHODS: A total of 1,163 cases with ovarian cancer (n=551), endometrial cancer (n=440) and cervical cancer (n=172) were involved in the study. The control group was formed from 22,581 female blood donors. Blood groups were determined through patients medical records and blood donor records. Odds ratios (OR) with 95% confidence intervals (CI) were calculated. The blood group O was defined as the referent group, as it has the greatest frequency in the populations of Southern Siberia. P values less than 0.05 were regarded as statistically significant.
We found that carriage of non-O blood types increased the risk of ovarian cancer by 40-60%, and the magnitude of this relationship was strongest in women with the AB (IV) blood group. Carriage of the A (II) blood group strongly correlated with an increased risk of ovarian cancer in premenopausal, but not in postmenopausal women. No statistically significant correlations were obtained for endometrial cancer and cervical cancer. Additionally, we did not observe a relationship between Rhesus factor and cancer risk.
We suggest that carriage of non-O blood groups may elevate risk of ovarian cancer and can play a role in its development.
有大量证据表明ABO血型系统可能在疾病病因学中发挥作用。多项研究已证实ABO血型与恒河猴血型和癌症风险之间存在关联。然而，对于妇科恶性肿瘤，这些发现并不一致且相互矛盾。
进行一项病例对照研究，以分析来自西伯利亚东南部患有卵巢癌、子宫内膜癌和宫颈癌的女性中ABO和Rh血型抗原的分布情况，并评估这些抗原在致癌过程中的潜在作用。
设计、研究对象与方法：共有1163例患有卵巢癌（n = 551）、子宫内膜癌（n = 440）和宫颈癌（n = 172）的患者参与了本研究。对照组由22581名女性献血者组成。通过患者病历和献血者记录确定血型。计算比值比（OR）及其95%置信区间（CI）。将O型血定义为参照组，因为它在西伯利亚南部人群中出现频率最高。P值小于0.05被视为具有统计学意义。
我们发现非O型血的携带增加了40% - 60%的卵巢癌风险，这种关系在AB（IV）血型的女性中最为强烈。A（II）血型的携带与绝经前女性卵巢癌风险增加密切相关，但在绝经后女性中并非如此。对于子宫内膜癌和宫颈癌，未获得具有统计学意义的相关性。此外，我们未观察到恒河猴因子与癌症风险之间的关系。
我们认为非O型血的携带可能会增加卵巢癌风险，并在其发展过程中发挥作用。
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