Department of Pneumology and Critical Care Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057, Rostock, Germany.
Respir Res. 2012 Dec 17;13(1):116. doi: 10.1186/1465-9921-13-116.
Chronic Obstructive Pulmonary Disease (COPD) is characterised by complex inflammatory, neuronal and fibrotic changes. Brain-derived Neurotrophic Factor (BDNF) is a key regulator of neuronal plasticity, whereas Transforming Growth Factor-β1 (TGF-β1) plays a crucial role in tissue repair and emphysema pathogenesis. Both mediators are stored in platelets and released from platelets in inflammatory conditions and during serum preparation. In patients with asthma, it was previously shown that elevated serum BDNF concentrations correlate with disease severity, whereas TGF-β1 concentrations were normal.
In the present study, 63 patients with stable COPD (spirometric GOLD stages 2-4) and 17 age- and comorbidity-matched controls were studied. Lung function, smoking history, medication, platelet concentrations in peripheral blood and serum concentrations of BDNF, TGF-β1 and Serotonin (5-HT) were assessed in all participants.
Serum levels of both BDNF and TGF-β1 (but not concentrations of platelets in peripheral blood) were significantly elevated in all stages of COPD as compared to controls. Highest BDNF concentrations were found in spirometric GOLD stage 3, whereas highest TGF-β1 serum levels were found in spirometric GOLD stage 4. There were specific, stage-dependent correlations of these mediators with lung function parameters of the patients.
Taken together, we show that, in contrast to asthma, COPD is characterised by elevated concentrations of both BDNF and TGF-β1 in serum. The stage-dependent association with lung function supports the hypothesis that these platelet mediators may play a role in the pathogenesis of COPD.
慢性阻塞性肺疾病（COPD）的特征是复杂的炎症、神经元和纤维化变化。脑源性神经营养因子（BDNF）是神经元可塑性的关键调节剂，而转化生长因子-β1（TGF-β1）在组织修复和肺气肿发病机制中起着至关重要的作用。这两种介质都储存在血小板中，并在炎症条件下和血清制备过程中从血小板中释放出来。以前的研究表明，在哮喘患者中，升高的血清 BDNF 浓度与疾病严重程度相关，而 TGF-β1 浓度正常。
本研究纳入了 63 例稳定期 COPD 患者（肺功能 GOLD 分期 2-4 期）和 17 例年龄和合并症相匹配的对照者。所有参与者均评估了肺功能、吸烟史、药物治疗、外周血血小板浓度以及血清 BDNF、TGF-β1 和 5-羟色胺（5-HT）浓度。
与对照组相比，COPD 的所有阶段的血清 BDNF 和 TGF-β1 水平（但外周血血小板浓度除外）均显著升高。在肺功能 GOLD 分期 3 期，BDNF 浓度最高，而在肺功能 GOLD 分期 4 期，TGF-β1 血清水平最高。这些介质与患者的肺功能参数存在特定的、与分期相关的相关性。
总的来说，我们表明，与哮喘相反，COPD 的特征是血清中 BDNF 和 TGF-β1 浓度升高。与肺功能的分期相关性支持了这样一种假设，即这些血小板介质可能在 COPD 的发病机制中发挥作用。
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