Barking, Havering and Redbridge University Hospitals NHS Trust, Rheumatology and Rehabilitation, King George Hospital, Barley Lane, Goodmayes, Ilford IG3 8YB, UK.
Clin Rheumatol. 2013 May;32(5):591-9. doi: 10.1007/s10067-012-2139-5. Epub 2012 Dec 18.
To test for demographic and clinical differences between Caucasian and South Asian patients with psoriatic arthritis (PsA) living in the same environment and for differences between sexes. The demographic characteristics of patients attending outpatient clinics were obtained using a semi-structured questionnaire. Clinical parameters included disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR), C-reactive protein), function (Bath Ankylosing Spondylitis Functional Index (BASFI)) and visual analogue scale (VAS) scores for well-being and night pain (10 cm, where 10 = worst possible response). The first symptom experienced at disease onset and the main symptoms during the disease course were recorded in the questionnaire. A total of 217 patents were assessed of whom 151 were Caucasians and 66 were Asians. South Asian patients were significantly younger [(mean) 45.9 years [(SD)(±11.4)] for Asians and 53.1 years (±14.2) for Caucasians (p < 0.005)] and were diagnosed at an earlier age [40.7 years (±11.7) for Asians and 46.7 years (±15.8) for Caucasians (p < 0.05)] compared to Caucasians patients. Asian females with PsA had worse disease in terms of activity (ESR = 23.9 mmHg/h; BASDAI = 6.7), function (BASFI = 5.5), night pain (7.1 on VAS) and well-being (6.6 on VAS) compared with Asian males (13.2 mmHg/h, 5.3, 3.6, 4.1, 4.6, respectively) or Caucasian males and females (15.8 mmHg/h, 5.9, 5.3, 5.4, 5.4; 18.9 mmHg/h, 6.1, 6.1, 5.3, 5.8, respectively). There were no significant differences in symptoms at disease onset or the main symptoms during the disease course between Caucasian and Asian patients, although there was a trend towards more frequent enthesitis in Asian females during the course of disease suggested by pain with pressure compared to Asian males. South Asian patients may develop PsA earlier in life than Caucasian patients do, but their clinical characteristics are generally similar. Asian females with PsA have worse disease activity, function, night pain and well-being than Asian males and Caucasian males and females.
为了测试生活在同一环境中的白种人和南亚银屑病关节炎（PsA）患者之间的人口统计学和临床差异，以及性别之间的差异。使用半结构化问卷获得门诊患者的人口统计学特征。临床参数包括疾病活动度（Bath 强直性脊柱炎疾病活动指数（BASDAI）、红细胞沉降率（ESR）、C 反应蛋白）、功能（Bath 强直性脊柱炎功能指数（BASFI））和幸福感及夜间疼痛的视觉模拟评分（VAS）（10cm，其中 10 为最差可能反应）。问卷中记录了疾病发病时的首发症状和疾病过程中的主要症状。共评估了 217 例患者，其中 151 例为白种人，66 例为亚洲人。南亚患者明显更年轻[（平均）45.9 岁[（SD）（±11.4）]为亚洲人，53.1 岁（±14.2）为白种人（p<0.005）]，诊断年龄也更早[40.7 岁（±11.7）为亚洲人，46.7 岁（±15.8）为白种人（p<0.05）]。与白种人相比，患有 PsA 的亚洲女性在疾病活动度（ESR=23.9mmHg/h；BASDAI=6.7）、功能（BASFI=5.5）、夜间疼痛（VAS 上的 7.1）和幸福感（VAS 上的 6.6）方面病情更差与亚洲男性（分别为 13.2mmHg/h、5.3、3.6、4.1、4.6）或白种人男性和女性（15.8mmHg/h、5.9、5.3、5.4、5.4；18.9mmHg/h、6.1、6.1、5.3、5.8）相比。白种人和亚洲患者在疾病发病时的症状或疾病过程中的主要症状方面没有显著差异，但在疾病过程中，亚洲女性的压痛比亚洲男性更频繁地出现附着点炎，这表明疾病有加重趋势。南亚患者可能比白种人更早发病，但他们的临床特征通常相似。患有 PsA 的亚洲女性的疾病活动度、功能、夜间疼痛和幸福感均比亚洲男性和白种人男性和女性差。
