Department of Anatomy, University of Rostock Rostock, Germany.
Front Neural Circuits. 2012 Dec 11;6:81. doi: 10.3389/fncir.2012.00081. eCollection 2012.
The connectomes of nervous systems or parts there of are becoming important subjects of study as the amount of connectivity data increases. Because most tract-tracing studies are performed on the rat, we conducted a comprehensive analysis of the amygdala connectome of this species resulting in a meta-study. The data were imported into the neuroVIISAS system, where regions of the connectome are organized in a controlled ontology and network analysis can be performed. A weighted digraph represents the bilateral intrinsic (connections of regions of the amygdala) and extrinsic (connections of regions of the amygdala to non-amygdaloid regions) connectome of the amygdala. Its structure as well as its local and global network parameters depend on the arrangement of neuronal entities in the ontology. The intrinsic amygdala connectome is a small-world and scale-free network. The anterior cortical nucleus (72 in- and out-going edges), the posterior nucleus (45), and the anterior basomedial nucleus (44) are the nuclear regions that posses most in- and outdegrees. The posterior nucleus turns out to be the most important nucleus of the intrinsic amygdala network since its Shapley rate is minimal. Within the intrinsic amygdala, regions were determined that are essential for network integrity. These regions are important for behavioral (processing of emotions and motivation) and functional (memory) performances of the amygdala as reported in other studies.
神经系统或其部分的连接组学正成为研究的重要课题，因为连接数据的数量不断增加。由于大多数追踪研究都是在大鼠上进行的，我们对这种物种的杏仁核连接组进行了全面分析，得出了一项元研究。这些数据被导入到 neuroVIISAS 系统中，在这个系统中，连接组的区域被组织在一个受控的本体中，可以进行网络分析。一个加权有向图表示杏仁核的双侧内在（杏仁核区域的连接）和外在（杏仁核区域与非杏仁核区域的连接）连接组。它的结构及其局部和全局网络参数取决于本体中神经元实体的排列。内在杏仁核连接组是一个小世界和无标度网络。前皮质核（72 个传入和传出边缘）、后核（45 个）和前基底内侧核（44 个）是具有最多传入和传出度的核区。由于其 Shapley 率最小，后核成为内在杏仁核网络中最重要的核。在内在杏仁核中，确定了对网络完整性至关重要的区域。这些区域对于杏仁核的行为（情绪和动机处理）和功能（记忆）表现是重要的，正如其他研究报告的那样。
