Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute Jena (HKI), Beutenbergstrasse 11a, 07745 Jena, Germany.
Cell Microbiol. 2013 May;15(5):701-8. doi: 10.1111/cmi.12091. Epub 2013 Jan 14.
Candida albicans and C. glabrata are the two most common pathogenic yeasts of humans, yet they are phylogenetically, genetically and phenotypically very different. In this review, we compare and contrast the strategies of C. albicans and C. glabrata to attach to and invade into the host, obtain nutrients and evade the host immune response. Although their strategies share some basic concepts, they differ greatly in their outcome. While C. albicans follows an aggressive strategy to subvert the host response and to obtain nutrients for its survival, C. glabrata seems to have evolved a strategy which is based on stealth, evasion and persistence, without causing severe damage in murine models. However, both fungi are successful as commensals and as pathogens of humans. Understanding these strategies will help in finding novel ways to fight Candida, and fungal infections in general.
白色念珠菌和光滑念珠菌是两种最常见的人类致病性酵母菌，但它们在系统发生、遗传和表型上有很大的不同。在这篇综述中，我们比较和对比了白色念珠菌和光滑念珠菌附着和入侵宿主、获取营养和逃避宿主免疫反应的策略。尽管它们的策略有一些共同的基本概念，但结果却大不相同。虽然白色念珠菌采取了一种激进的策略来颠覆宿主的反应并获取其生存所需的营养，但光滑念珠菌似乎已经进化出一种基于隐匿、逃避和持续存在的策略，而不会在小鼠模型中造成严重损害。然而，这两种真菌都是人类共生菌和病原体。了解这些策略将有助于寻找新的方法来对抗念珠菌，以及一般的真菌感染。
