Department of Oral Health and Systemic Disease, University of Louisville, Louisville, KY 40202, USA.
Mol Oral Microbiol. 2013 Apr;28(2):83-101. doi: 10.1111/omi.12012. Epub 2012 Dec 17.
Establishment of a community is considered to be essential for microbial growth and survival in the human oral cavity. Biofilm communities have increased resilience to physical forces, antimicrobial agents and nutritional variations. Specific cell-to-cell adherence processes, mediated by adhesin-receptor pairings on respective microbial surfaces, are able to direct community development. These interactions co-localize species in mutually beneficial relationships, such as streptococci, veillonellae, Porphyromonas gingivalis and Candida albicans. In transition from the planktonic mode of growth to a biofilm community, microorganisms undergo major transcriptional and proteomic changes. These occur in response to sensing of diffusible signals, such as autoinducer molecules, and to contact with host tissues or other microbial cells. Underpinning many of these processes are intracellular phosphorylation events that regulate a large number of microbial interactions relevant to community formation and development.
社区的建立被认为对微生物在人类口腔中的生长和存活至关重要。生物膜群落对物理力、抗菌剂和营养变化的抵抗力增强。特定的细胞间粘附过程，由各自微生物表面上的粘附素-受体配对介导，能够指导群落的发展。这些相互作用将物种集中在互利关系中，例如链球菌、韦荣球菌、牙龈卟啉单胞菌和白色念珠菌。在从浮游生长模式转变为生物膜群落的过程中，微生物经历了主要的转录组和蛋白质组变化。这些变化是对可扩散信号（如自诱导分子）的感应以及与宿主组织或其他微生物细胞的接触的反应。许多这些过程的基础是细胞内磷酸化事件，这些事件调节与群落形成和发展相关的大量微生物相互作用。
