C 反应蛋白与墨西哥裔美国人阿尔茨海默病的关联。
The link between C-reactive protein and Alzheimer's disease among Mexican Americans.
机构信息
University of North Texas Health Sciences Center, Department of Internal Medicine, Fort Worth, TX 76107, USA. sid.o’
出版信息
J Alzheimers Dis. 2013;34(3):701-6. doi: 10.3233/JAD-122071.
BACKGROUND
The aim of this study is to evaluate the link between C-reactive protein (CRP) and Alzheimer's disease (AD) and mild cognitive impairment (MCI) among Mexican Americans.
METHODS
Non-fasting serum CRP levels, Mini-Mental State Examination scores, and Clinical Dementia Rating scale (CDR) scores were analyzed from 1,066 participants (Mexican American n = 471; non-Hispanic n = 595) of the Texas Alzheimer's Research & Care Consortium.
RESULTS
Among the total cohort, CRP levels among AD cases were significantly decreased as compared to normal controls (p < 0.001) and MCI cases (p = 0.002). CRP levels among MCI cases were decreased relative to controls (p = 0.03). Among Mexican American and non-Hispanic AD cases, CRP levels were significantly decreased among AD cases as compared to controls. CRP levels were only associated with disease severity (CDR scores) among non-Hispanics (p = 0.03) AD cases.
CONCLUSIONS
These results show that while CRP levels are decreased among Mexican American AD cases, CRP does not appear to be related to clinical variables as it is among non-Hispanic whites.
背景
本研究旨在评估 C 反应蛋白（CRP）与墨西哥裔美国人中阿尔茨海默病（AD）和轻度认知障碍（MCI）之间的关联。
方法
从德克萨斯州阿尔茨海默病研究与护理联合会的 1066 名参与者（墨西哥裔美国人 n = 471；非西班牙裔 n = 595）中分析了非禁食血清 CRP 水平、简易精神状态检查评分和临床痴呆评定量表（CDR）评分。
结果
在总队列中，AD 病例的 CRP 水平明显低于正常对照组（p < 0.001）和 MCI 病例（p = 0.002）。MCI 病例的 CRP 水平较对照组降低（p = 0.03）。在墨西哥裔美国人和非西班牙裔 AD 病例中，AD 病例的 CRP 水平明显低于对照组。CRP 水平仅与非西班牙裔 AD 病例的疾病严重程度（CDR 评分）相关（p = 0.03）。
结论
这些结果表明，虽然 CRP 水平在墨西哥裔美国 AD 病例中降低，但与非西班牙裔白人相比，CRP 似乎与临床变量无关。
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