Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, TX, USA.
Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.
J Alzheimers Dis. 2022;90(2):905-915. doi: 10.3233/JAD-220300.
Despite tremendous advancements in the field, our understanding of mild cognitive impairment (MCI) and Alzheimer's disease (AD) among Mexican Americans remains limited.
The aim of this study was to characterize MCI and dementia among Mexican Americans and non-Hispanic whites.
Baseline data were analyzed from n = 1,705 (n = 890 Mexican American; n = 815 non-Hispanic white) participants enrolled in the Health and Aging Brain Study-Health Disparities (HABS-HD).
Among Mexican Americans, age (OR = 1.07), depression (OR = 1.09), and MRI-based neurodegeneration (OR = 0.01) were associated with dementia, but none of these factors were associated with MCI. Among non-Hispanic whites, male gender (OR = 0.33), neighborhood deprivation (OR = 1.34), depression (OR = 1.09), and MRI-based neurodegeneration (OR = 0.03) were associated with MCI, while depression (OR = 1.09) and APOEɛ4 genotype (OR = 4.38) were associated with dementia.
Findings from this study revealed that the demographic, clinical, sociocultural and biomarker characteristics of MCI and dementia are different among Mexican Americans as compared to non-Hispanic whites.
尽管该领域取得了巨大进展，但我们对墨西哥裔美国人的轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 的理解仍然有限。
本研究旨在描述墨西哥裔美国人和非西班牙裔白人间的 MCI 和痴呆情况。
分析了来自参加健康与衰老大脑研究-健康差异 (HABS-HD) 的 n=1705 名参与者（n=890 名墨西哥裔美国人；n=815 名非西班牙裔白人）的基线数据。
在墨西哥裔美国人中，年龄（OR=1.07）、抑郁（OR=1.09）和基于 MRI 的神经退行性变（OR=0.01）与痴呆有关，但这些因素均与 MCI 无关。在非西班牙裔白人中，男性（OR=0.33）、社区贫困（OR=1.34）、抑郁（OR=1.09）和基于 MRI 的神经退行性变（OR=0.03）与 MCI 有关，而抑郁（OR=1.09）和 APOEɛ4 基因型（OR=4.38）与痴呆有关。
本研究结果表明，与非西班牙裔白人相比，墨西哥裔美国人的 MCI 和痴呆的人口统计学、临床、社会文化和生物标志物特征有所不同。
