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Mitogen-induced differentiation of human CLL lymphocytes to antibody-secreting cells.

作者信息

Robèrt K H, Bird A G, Möller E

出版信息

Scand J Immunol. 1979;10(5):447-52. doi: 10.1111/j.1365-3083.1979.tb01374.x.

DOI:10.1111/j.1365-3083.1979.tb01374.x
PMID:232570
Abstract

Peripheral blood lymphocytes from nine patients with chronic lymphatic leukaemia (CLL) have been stimulated by photohaemagglutinin, pokeweed mitogen and Epstein-Barr virus. Our results provide proof that the leukaemic B cells in CLL are capable of responding to mitogenic signals by producing and secreting antibodies, transforming into blast cells, and, probably, increasing their rate of DNA synthesis.

摘要

相似文献

1
Mitogen-induced differentiation of human CLL lymphocytes to antibody-secreting cells.
Scand J Immunol. 1979;10(5):447-52. doi: 10.1111/j.1365-3083.1979.tb01374.x.
2
Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes.丝裂原刺激的慢性淋巴细胞白血病淋巴细胞的免疫球蛋白产生
Clin Exp Immunol. 1982 Mar;47(3):697-705.
3
The roles of leukaemic and residual normal cells in the proliferative response of chronic lymphocytic leukaemic lymphocytes to mitogens.白血病细胞和残留正常细胞在慢性淋巴细胞白血病淋巴细胞对有丝分裂原增殖反应中的作用。
Clin Exp Immunol. 1982 Mar;47(3):689-96.
4
Mitogen-induced maturation of chronic lymphocytic leukemia B lymphocytes.丝裂原诱导的慢性淋巴细胞白血病B淋巴细胞成熟
J Clin Immunol. 1982 Jul;2(3):186-96. doi: 10.1007/BF00915221.
5
Induction of monoclonal antibody synthesis in malignant human B cells by polyclonal B cell activators. Relationship between B cell subsets and prognosis.多克隆B细胞激活剂诱导恶性人类B细胞中单克隆抗体的合成。B细胞亚群与预后之间的关系。
Immunol Rev. 1979;48:123-43. doi: 10.1111/j.1600-065x.1979.tb00301.x.
6
Stimulation of chronic lymphatic leukaemia cells by pokeweed mitogen after treatment with neuraminidase-galactose oxidase.用神经氨酸酶 - 半乳糖氧化酶处理后,美洲商陆丝裂原对慢性淋巴细胞白血病细胞的刺激作用。
Clin Exp Immunol. 1981 Apr;44(1):124-8.
7
Interaction of Epstein-Barr virus with leukaemic B cells in vitro. I. Abortive infection and rare cell line establishment from chronic lymphocytic leukaemic cells.爱泼斯坦-巴尔病毒与白血病B细胞的体外相互作用。I. 慢性淋巴细胞白血病细胞的流产感染及稀有细胞系的建立
Clin Exp Immunol. 1982 Nov;50(2):347-54.
8
Mitogenic stimulation of malignant B cells. Chronic lymphocytic leukaemia: relationship between stimulation and surface phenotype.恶性B细胞的有丝分裂原刺激。慢性淋巴细胞白血病:刺激与表面表型之间的关系。
Clin Exp Immunol. 1982 Nov;50(2):355-9.
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Human B lymphocytes activated by Epstein-Barr virus (EBV) or by mitogens suppress mitogen-induced immunoglobulin production.由爱泼斯坦-巴尔病毒(EBV)或有丝分裂原激活的人B淋巴细胞会抑制有丝分裂原诱导的免疫球蛋白产生。
J Immunol. 1981 May;126(5):1810-3.
10
[Contribution of new methods of quantitative cytology and immunology to the understanding of lymphoproliferative syndromes].[定量细胞学和免疫学新方法对淋巴增生综合征认识的贡献]
C R Seances Soc Biol Fil. 1979;173(2):213-20.

引用本文的文献

1
Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective.慢性淋巴细胞白血病 B 细胞正常细胞对应物:从功能角度得到的线索。
Front Immunol. 2018 Apr 4;9:683. doi: 10.3389/fimmu.2018.00683. eCollection 2018.
2
Mitogenic stimulation of malignant B cells. Chronic lymphocytic leukaemia: relationship between stimulation and surface phenotype.恶性B细胞的有丝分裂原刺激。慢性淋巴细胞白血病:刺激与表面表型之间的关系。
Clin Exp Immunol. 1982 Nov;50(2):355-9.
3
Mitogen-induced maturation of chronic lymphocytic leukemia B lymphocytes.
丝裂原诱导的慢性淋巴细胞白血病B淋巴细胞成熟
J Clin Immunol. 1982 Jul;2(3):186-96. doi: 10.1007/BF00915221.
4
Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes.丝裂原刺激的慢性淋巴细胞白血病淋巴细胞的免疫球蛋白产生
Clin Exp Immunol. 1982 Mar;47(3):697-705.
5
Mitogenic stimulation of malignant B cells. Chronic lymphocytic leukaemia: secretion of monoclonal IgM by in vitro-induced plasmablasts.恶性B细胞的有丝分裂原刺激。慢性淋巴细胞白血病:体外诱导的浆母细胞分泌单克隆IgM。
Clin Exp Immunol. 1984 Mar;55(3):636-42.
6
Interaction of Epstein-Barr virus with leukaemic B cells in vitro. I. Abortive infection and rare cell line establishment from chronic lymphocytic leukaemic cells.爱泼斯坦-巴尔病毒与白血病B细胞的体外相互作用。I. 慢性淋巴细胞白血病细胞的流产感染及稀有细胞系的建立
Clin Exp Immunol. 1982 Nov;50(2):347-54.
7
Interleukin 2-induced proliferation of leukemic human B cells.白细胞介素2诱导人白血病B细胞增殖。
J Exp Med. 1985 May 1;161(5):1225-30. doi: 10.1084/jem.161.5.1225.
8
Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia.慢性淋巴细胞白血病患者中表达CD5的B淋巴细胞产生自身抗体。
J Exp Med. 1989 Jan 1;169(1):255-68. doi: 10.1084/jem.169.1.255.