Hamama Saad, Delanian Sylvie, Monceau Virginie, Vozenin Marie-Catherine
INSERM U-1030 "Molecular Radiotherapy" Institut Gustave Roussy, Villejuif, France ; "Molecular Radiotherapy", Université Paris Sud Paris XI, France.
INSERM U-1030 "Molecular Radiotherapy" Institut Gustave Roussy, Villejuif, France ; "Molecular Radiotherapy", Université Paris Sud Paris XI, France ; Unité de Radiopathologie, Service Oncologie-Radiothérapie, Hôpital Saint-Louis, APHP, Paris, France.
Fibrogenesis Tissue Repair. 2012 Jun 6;5(Suppl 1):S13. doi: 10.1186/1755-1536-5-S1-S13. eCollection 2012.
Chronic toxicities of locoregional and systemic oncological treatments commonly develop in long-term cancer survivors. Amongst these toxicities, post-radiotherapeutic complications alter patient's quality of life. Reduction of exposure of normal tissues can be achieved by optimization of radiotherapy. Furthermore, understanding of the fibrogenic mechanisms has provided targets to prevent, mitigate, and reverse late radiation-induced damages. This mini-review shows how (i) global molecular studies using gene profiling can provide tools to develop new intervention strategies and (ii) how successful clinical trials, conducted in particular with combined pentoxifylline-vitamin E, can take benefice of biological and molecular evidences to improve our understanding of fibrogenic mechanisms, enhance the robustness of proposed treatments, and lead ultimately to better treatments for patient's benefice.
局部和全身肿瘤治疗的慢性毒性在长期癌症幸存者中很常见。在这些毒性中，放射治疗后的并发症会改变患者的生活质量。通过优化放射治疗可以减少正常组织的暴露。此外，对纤维化机制的了解为预防、减轻和逆转晚期辐射损伤提供了靶点。这篇小型综述展示了：（i）使用基因谱分析的全球分子研究如何能够提供开发新干预策略的工具；（ii）特别是联合使用己酮可可碱-维生素E进行的成功临床试验如何能够利用生物学和分子证据来增进我们对纤维化机制的理解，增强所提议治疗的稳健性，并最终为患者带来更好的治疗效果。
