Max Bergmann Center of Biomaterials and Institute of Materials Science, Technische Universität Dresden, Dresden, Germany.
Acta Biomater. 2013 Apr;9(4):6199-207. doi: 10.1016/j.actbio.2012.12.017. Epub 2012 Dec 20.
Calcium phosphate cements (CPCs) are highly valuable materials for filling bone defects and bone augmentation by minimal invasive application via percutaneous injection. In the present study some key features were significantly improved by developing a novel injectable ready-to-use calcium phosphate cement based on water-immiscible carrier liquids. A combination of two surfactants was identified to facilitate the targeted discontinuous exchange of the liquid for water after contact with aqueous solutions, enabling the setting reaction to take place at distinct ratios of cement components to water. This prolonged the shelf life of the pre-mixed paste and enhanced reproducibility during application and setting reactions. The developed paste technology is applicable for different CPC formulations. Evaluations were performed for the formulation of an α-TCP-based CPC as a representative example for the preparation of injectable pastes with a powder-to-carrier liquid ratio of up to 85:15. We demonstrate that the resulting material retains the desirable properties of conventional CPC counterparts for fast setting, mechanical strength and biocompatibility, shows improved cohesion and will most probably show a similar degree of resorbability due to identical mineral structure of the set products.
磷酸钙骨水泥 (CPCs) 是一种非常有价值的材料，可通过经皮注射微创应用来填充骨缺损和增强骨。在本研究中，通过开发一种新型的可注射即用型磷酸钙骨水泥，基于不混水的载体液体，显著改善了一些关键特性。确定了两种表面活性剂的组合，以促进在与水溶液接触后将液体有针对性地间断交换为水，从而使凝固反应在水泥成分与水的不同比例下发生。这延长了预混合糊剂的保质期，并增强了应用和凝固反应过程中的可重复性。所开发的糊剂技术适用于不同的 CPC 配方。以基于 α-TCP 的 CPC 的配方为例，对制剂进行了评估，该配方代表了一种可注射糊剂的制备，其粉末与载体液体的比例高达 85:15。我们证明，所得材料保留了传统 CPC 对应物的快速凝固、机械强度和生物相容性等理想特性，显示出更好的内聚性，由于凝固产物的矿物结构相同，很可能表现出类似程度的可吸收性。
